Fields »
ABOUT
HELP
BLOG
PSMC4

GENERAL INFORMATION

Gene name

 PSMC4

Gene description

 Proteasome 26S subunit, ATPase 4

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in all tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA002044 , HPA005471
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PSMC4 (HGNC Symbol)

Synonyms

 MGC13687, MGC23214, MGC8570, MIP224, S6, TBP-7, TBP7

Description

 Proteasome 26S subunit, ATPase 4 (HGNC Symbol)

Entrez gene summary

 The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 39971005 - 39981441

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000013275 (version 83.38)

Entrez gene

 5704

UniProt

 P43686 (UniProt - Evidence at protein level)

neXtProt

 NX_P43686

Antibodypedia

 PSMC4 antibodies

PROTEIN BROWSER
PSMC4-001
PSMC4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PSMC4-001
ENSP00000157812
ENST00000157812
P43686 [Direct mapping]
26S protease regulatory subunit 6B
A8K2M0 [Target identity:100%; Query identity:100%]
Proteasome (Prosome, macropain) 26S subunit, ATPase, 4, isoform CRA_b; cDNA FLJ78505, highly similar to Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 4 (PSMC4), transcript variant 1, mRNA; cDNA, FLJ93682, Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 4(PSMC4), transcript variant 1, mRNA
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000502 [proteasome complex]
GO:0001824 [blastocyst development]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008540 [proteasome regulatory particle, base subcomplex]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016234 [inclusion body]
GO:0016787 [hydrolase activity]
GO:0016887 [ATPase activity]
GO:0017025 [TBP-class protein binding]
GO:0022624 [proteasome accessory complex]
GO:0030163 [protein catabolic process]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031595 [nuclear proteasome complex]
GO:0031597 [cytosolic proteasome complex]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0036402 [proteasome-activating ATPase activity]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045899 [positive regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
Show all
 418 aa
47.4 kDa 		No 0
PSMC4-002
ENSP00000413869
ENST00000455878
P43686 [Direct mapping]
26S protease regulatory subunit 6B
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000502 [proteasome complex]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008540 [proteasome regulatory particle, base subcomplex]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016787 [hydrolase activity]
GO:0016887 [ATPase activity]
GO:0017025 [TBP-class protein binding]
GO:0022624 [proteasome accessory complex]
GO:0030163 [protein catabolic process]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031595 [nuclear proteasome complex]
GO:0031597 [cytosolic proteasome complex]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0036402 [proteasome-activating ATPase activity]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045899 [positive regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
Show all
 387 aa
43.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.