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POLR3B

GENERAL INFORMATION

Gene name

 POLR3B

Gene description

 Polymerase (RNA) III (DNA directed) polypeptide B

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Supported based on 1 antibody.
HPA036466
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036466

GENE INFORMATION

Gene name

 POLR3B (HGNC Symbol)

Synonyms

 FLJ10388, RPC2

Description

 Polymerase (RNA) III (DNA directed) polypeptide B (HGNC Symbol)

Entrez gene summary

 This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Chromosome

 12

Cytoband

 q23.3

Chromosome location (bp)

 106357658 - 106510198

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000013503 (version 83.38)

Entrez gene

 55703

UniProt

 Q9NW08 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NW08

Antibodypedia

 POLR3B antibodies

PROTEIN BROWSER
POLR3B-001
POLR3B-003
POLR3B-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLR3B-001
ENSP00000228347
ENST00000228347
Q9NW08 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC2
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
RNA polymerase related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0032549 [ribonucleoside binding]
GO:0032728 [positive regulation of interferon-beta production]
GO:0045087 [innate immune response]
GO:0045089 [positive regulation of innate immune response]
GO:0046872 [metal ion binding]
GO:0051607 [defense response to virus]
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 1133 aa
127.8 kDa 		No 0
POLR3B-003
ENSP00000445721
ENST00000539066
Q9NW08 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC2
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
RNA polymerase related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0032549 [ribonucleoside binding]
GO:0032728 [positive regulation of interferon-beta production]
GO:0045087 [innate immune response]
GO:0045089 [positive regulation of innate immune response]
GO:0046872 [metal ion binding]
GO:0051607 [defense response to virus]
Show all
 1075 aa
121.1 kDa 		No 0
POLR3B-004
ENSP00000448398
ENST00000549569
F8VRU2 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC2
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0032549 [ribonucleoside binding]
Show all
 170 aa
19.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.