We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Polymerase (RNA) III (DNA directed) polypeptide B (HGNC Symbol)
Entrez gene summary
This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Q9NW08 [Direct mapping] DNA-directed RNA polymerase III subunit RPC2
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins RNA polymerase related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005654 [nucleoplasm] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006383 [transcription from RNA polymerase III promoter] GO:0006385 [transcription elongation from RNA polymerase III promoter] GO:0006386 [termination of RNA polymerase III transcription] GO:0010467 [gene expression] GO:0032481 [positive regulation of type I interferon production] GO:0032549 [ribonucleoside binding] GO:0032728 [positive regulation of interferon-beta production] GO:0045087 [innate immune response] GO:0045089 [positive regulation of innate immune response] GO:0046872 [metal ion binding] GO:0051607 [defense response to virus]
Q9NW08 [Direct mapping] DNA-directed RNA polymerase III subunit RPC2
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins RNA polymerase related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005654 [nucleoplasm] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006383 [transcription from RNA polymerase III promoter] GO:0006385 [transcription elongation from RNA polymerase III promoter] GO:0006386 [termination of RNA polymerase III transcription] GO:0010467 [gene expression] GO:0032481 [positive regulation of type I interferon production] GO:0032549 [ribonucleoside binding] GO:0032728 [positive regulation of interferon-beta production] GO:0045087 [innate immune response] GO:0045089 [positive regulation of innate immune response] GO:0046872 [metal ion binding] GO:0051607 [defense response to virus]
