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Malate dehydrogenase 1, NAD (soluble) (HGNC Symbol)
Entrez gene summary
This gene encodes an enzyme that catalyzes the reversible oxidation of malate to oxaloacetate using the NAD/NADH cofactor system in the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one found in the mitochondrial matrix and the other in the cytoplasm. This protein represents the cytosolic isozyme, which has a pivotal role in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. A recent study showed that two protein isoforms are produced from this mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism, and that these C-terminally distinct isoforms have different subcellular localization. Alternatively spliced transcript variants have also been found for this gene. Pseudogenes have been identified on chromosomes X and 6. [provided by RefSeq, Oct 2015]
Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002230 [positive regulation of defense response to virus by host] GO:0003824 [catalytic activity] GO:0004470 [malic enzyme activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006099 [tricarboxylic acid cycle] GO:0006108 [malate metabolic process] GO:0016491 [oxidoreductase activity] GO:0016615 [malate dehydrogenase activity] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0019752 [carboxylic acid metabolic process] GO:0030060 [L-malate dehydrogenase activity] GO:0044281 [small molecule metabolic process] GO:0047860 [diiodophenylpyruvate reductase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0098779 [mitophagy in response to mitochondrial depolarization]
Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] GO:0006108 [malate metabolic process] GO:0016615 [malate dehydrogenase activity] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0055114 [oxidation-reduction process]
Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] GO:0006108 [malate metabolic process] GO:0016615 [malate dehydrogenase activity] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0055114 [oxidation-reduction process]
Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002230 [positive regulation of defense response to virus by host] GO:0003824 [catalytic activity] GO:0004470 [malic enzyme activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006099 [tricarboxylic acid cycle] GO:0006107 [oxaloacetate metabolic process] GO:0006108 [malate metabolic process] GO:0006734 [NADH metabolic process] GO:0016491 [oxidoreductase activity] GO:0016615 [malate dehydrogenase activity] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0019674 [NAD metabolic process] GO:0019752 [carboxylic acid metabolic process] GO:0030060 [L-malate dehydrogenase activity] GO:0043209 [myelin sheath] GO:0044281 [small molecule metabolic process] GO:0047860 [diiodophenylpyruvate reductase activity] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0098779 [mitophagy in response to mitochondrial depolarization]
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002230 [positive regulation of defense response to virus by host] GO:0003824 [catalytic activity] GO:0004470 [malic enzyme activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006099 [tricarboxylic acid cycle] GO:0006108 [malate metabolic process] GO:0016491 [oxidoreductase activity] GO:0016615 [malate dehydrogenase activity] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0030060 [L-malate dehydrogenase activity] GO:0044281 [small molecule metabolic process] GO:0047860 [diiodophenylpyruvate reductase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0098779 [mitophagy in response to mitochondrial depolarization]
