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BID

GENERAL INFORMATION

Gene name

 BID

Gene description

 BH3 interacting domain death agonist

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in lymphocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA000722 , CAB003771
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA000722
CAB003771

GENE INFORMATION

Gene name

 BID

Synonyms

Description

 BH3 interacting domain death agonist (HGNC Symbol)

Entrez gene summary

 This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q11.21

Chromosome location (bp)

 17734138 - 17774770

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000015475 (version 83.38)

Entrez gene

 637

UniProt

 P55957 (UniProt - Evidence at protein level)

neXtProt

 NX_P55957

Antibodypedia

 BID antibodies

PROTEIN BROWSER
«
BID-001
BID-002
BID-003
BID-004
BID-009
BID-201
BID-202
BID-203
BID-204
BID-205
BID-206
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BID-001
ENSP00000382674
ENST00000399774
P55957 [Direct mapping]
BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11
A8ASI8 [Target identity:100%; Query identity:100%]
BH3 interacting domain death agonist, isoform CRA_d; BID isoform L(2); Desmocollin type 4; cDNA, FLJ94329, Homo sapiens BH3 interacting domain death agonist (BID), mRNA
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008637 [apoptotic mitochondrial changes]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0032461 [positive regulation of protein oligomerization]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0051402 [neuron apoptotic process]
GO:0070062 [extracellular exosome]
GO:0090150 [establishment of protein localization to membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 195 aa
22 kDa 		No 0
BID-002
ENSP00000318822
ENST00000317361
P55957 [Direct mapping]
BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006626 [protein targeting to mitochondrion]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007420 [brain development]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008637 [apoptotic mitochondrial changes]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032355 [response to estradiol]
GO:0032459 [regulation of protein oligomerization]
GO:0032461 [positive regulation of protein oligomerization]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0032592 [integral component of mitochondrial membrane]
GO:0034349 [glial cell apoptotic process]
GO:0042127 [regulation of cell proliferation]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0051260 [protein homooligomerization]
GO:0051402 [neuron apoptotic process]
GO:0070062 [extracellular exosome]
GO:0090150 [establishment of protein localization to membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097284 [hepatocyte apoptotic process]
GO:0097345 [mitochondrial outer membrane permeabilization]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:1902108 [regulation of mitochondrial membrane permeability involved in apoptotic process]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 241 aa
26.8 kDa 		No 0
BID-003
ENSP00000344594
ENST00000342111
P55957 [Direct mapping]
BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008637 [apoptotic mitochondrial changes]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0032461 [positive regulation of protein oligomerization]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0042770 [signal transduction in response to DNA damage]
GO:0043065 [positive regulation of apoptotic process]
GO:0051402 [neuron apoptotic process]
GO:0070062 [extracellular exosome]
GO:0090150 [establishment of protein localization to membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 137 aa
14.6 kDa 		No 0
BID-004
ENSP00000382667
ENST00000399765
P55957 [Direct mapping]
BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11
B2ZP79 [Target identity:100%; Query identity:100%]
BH3 interacting domain death agonist, isoform CRA_b; BID isoform ES(1b)
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008637 [apoptotic mitochondrial changes]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0032461 [positive regulation of protein oligomerization]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0042770 [signal transduction in response to DNA damage]
GO:0043065 [positive regulation of apoptotic process]
GO:0051402 [neuron apoptotic process]
GO:0070062 [extracellular exosome]
GO:0090150 [establishment of protein localization to membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 99 aa
11.3 kDa 		No 0
BID-009
ENSP00000449236
ENST00000551952
P55957 [Direct mapping]
BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11
A8ASI8 [Target identity:100%; Query identity:100%]
BH3 interacting domain death agonist, isoform CRA_d; BID isoform L(2); Desmocollin type 4; cDNA, FLJ94329, Homo sapiens BH3 interacting domain death agonist (BID), mRNA
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008637 [apoptotic mitochondrial changes]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0032461 [positive regulation of protein oligomerization]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0051402 [neuron apoptotic process]
GO:0070062 [extracellular exosome]
GO:0090150 [establishment of protein localization to membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 195 aa
22 kDa 		No 0
BID-201
ENSP00000382669
ENST00000399767
P55957 [Direct mapping]
BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11
B2ZP79 [Target identity:100%; Query identity:100%]
BH3 interacting domain death agonist, isoform CRA_b; BID isoform ES(1b)
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008637 [apoptotic mitochondrial changes]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0032461 [positive regulation of protein oligomerization]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0042770 [signal transduction in response to DNA damage]
GO:0043065 [positive regulation of apoptotic process]
GO:0051402 [neuron apoptotic process]
GO:0070062 [extracellular exosome]
GO:0090150 [establishment of protein localization to membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 99 aa
11.3 kDa 		No 0
BID-202
ENSP00000483709
ENST00000611040
P55957 [Direct mapping]
BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11
B2ZP79 [Target identity:100%; Query identity:100%]
BH3 interacting domain death agonist, isoform CRA_b; BID isoform ES(1b)
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008637 [apoptotic mitochondrial changes]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0032461 [positive regulation of protein oligomerization]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0042770 [signal transduction in response to DNA damage]
GO:0043065 [positive regulation of apoptotic process]
GO:0051402 [neuron apoptotic process]
GO:0070062 [extracellular exosome]
GO:0090150 [establishment of protein localization to membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 99 aa
11.3 kDa 		No 0
BID-203
ENSP00000477773
ENST00000614949
P55957 [Direct mapping]
BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11
B2ZP79 [Target identity:100%; Query identity:100%]
BH3 interacting domain death agonist, isoform CRA_b; BID isoform ES(1b)
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008637 [apoptotic mitochondrial changes]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0032461 [positive regulation of protein oligomerization]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0042770 [signal transduction in response to DNA damage]
GO:0043065 [positive regulation of apoptotic process]
GO:0051402 [neuron apoptotic process]
GO:0070062 [extracellular exosome]
GO:0090150 [establishment of protein localization to membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 99 aa
11.3 kDa 		No 0
BID-204
ENSP00000483534
ENST00000615414
P55957 [Direct mapping]
BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11
B2ZP79 [Target identity:100%; Query identity:100%]
BH3 interacting domain death agonist, isoform CRA_b; BID isoform ES(1b)
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008637 [apoptotic mitochondrial changes]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0032461 [positive regulation of protein oligomerization]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0042770 [signal transduction in response to DNA damage]
GO:0043065 [positive regulation of apoptotic process]
GO:0051402 [neuron apoptotic process]
GO:0070062 [extracellular exosome]
GO:0090150 [establishment of protein localization to membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 99 aa
11.3 kDa 		No 0
BID-205
ENSP00000481991
ENST00000617586
B2ZP78 [Direct mapping]
BH3-interacting domain death agonist; BID isoform Si6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0043065 [positive regulation of apoptotic process]
Show all
 122 aa
13 kDa 		No 0
BID-206
ENSP00000480414
ENST00000622694
P55957 [Direct mapping]
BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11
A8ASI8 [Target identity:100%; Query identity:100%]
BH3 interacting domain death agonist, isoform CRA_d; BID isoform L(2); Desmocollin type 4; cDNA, FLJ94329, Homo sapiens BH3 interacting domain death agonist (BID), mRNA
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008637 [apoptotic mitochondrial changes]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0032461 [positive regulation of protein oligomerization]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0051402 [neuron apoptotic process]
GO:0070062 [extracellular exosome]
GO:0090150 [establishment of protein localization to membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 195 aa
22 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.