Cell atlas - RGPD5 - The Human Protein Atlas

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RGPD5

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane
	Vesicles

Human cell
	Nuclear membrane
	Vesicles

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GENERAL INFORMATION
Gene name	RGPD5
Gene description	RANBP2-like and GRIP domain containing 5
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear membrane & vesicles. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (uncertain), Vesicles (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA067564
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear membrane & vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nuclear membrane (uncertain), Vesicles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA067564	CACO-2	Nuclear membrane
	HPA067564	CACO-2	Vesicles
	HPA067564	RT4	Nuclear membrane
	HPA067564	RT4	Vesicles
	HPA067564	U-2 OS	Nuclear membrane
	HPA067564	U-2 OS	Vesicles

GENE INFORMATION
Gene name	RGPD5 (HGNC Symbol)
Synonyms	BS-63, DKFZp686I1842, RGP5
Description	RANBP2-like and GRIP domain containing 5 (HGNC Symbol)
Entrez gene summary	RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene shares a high degree of sequence identity with RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. It is believed that this RANBP2 gene family member arose from a duplication event 3 Mb distal to RANBP2. Alternative splicing has been observed for this locus and two variants are described. Additional splicing is suggested but complete sequence for further transcripts has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q13
Chromosome location (bp)	109792758 - 109857695
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000015568 (version 83.38)
Entrez gene	84220
UniProt	Q99666 (UniProt - Evidence at protein level)
neXtProt	NX_Q99666
Antibodypedia	RGPD5 antibodies

PROTEIN BROWSER

RGPD5-001	RGPD5-002	RGPD5-008	RGPD5-009	RGPD5-010	RGPD5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RGPD5-001 ENSP00000016946 ENST00000016946	Q99666 [Direct mapping] RANBP2-like and GRIP domain-containing protein 5/6 V9HWE4 [Target identity:100%; Query identity:100%] Epididymis luminal protein 161 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Show all	GO:0000042 [protein targeting to Golgi] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0046907 [intracellular transport] Show all	1765 aa 198.9 kDa	No	0
RGPD5-002 ENSP00000376962 ENST00000393283	Q99666 [Direct mapping] RANBP2-like and GRIP domain-containing protein 5/6 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Show all	GO:0000042 [protein targeting to Golgi] GO:0005515 [protein binding] GO:0005737 [cytoplasm] Show all	904 aa 103.3 kDa	No	0
RGPD5-008 ENSP00000392556 ENST00000430736	C9J1W9 [Direct mapping] RANBP2-like and GRIP domain-containing protein 5/6 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	134 aa 15.7 kDa	No	0
RGPD5-009 ENSP00000411548 ENST00000441344	C9J6W1 [Direct mapping] RANBP2-like and GRIP domain-containing protein 5/6; RANBP2-like and GRIP domain-containing protein 8 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	152 aa 18 kDa	No	0
RGPD5-010 ENSP00000400797 ENST00000432606	C9J1P2 [Direct mapping] RANBP2-like and GRIP domain-containing protein 5/6 Show all	Predicted intracellular proteins Show all		56 aa 6.8 kDa	No	0
RGPD5-201 ENSP00000272454 ENST00000272454	Q99666 [Direct mapping] RANBP2-like and GRIP domain-containing protein 5/6 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Show all	GO:0000042 [protein targeting to Golgi] GO:0005515 [protein binding] GO:0005737 [cytoplasm] Show all	904 aa 103.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.