Expression of CHDH in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CHDH
Gene description	Choline dehydrogenase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (Hep G2, T-47d)
HPA (normal tissue):	Tissue enhanced (kidney)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in several tissues, most abundant in renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA036633 , HPA058130
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA036633	HPA058130

GENE INFORMATION
Gene name	CHDH
Synonyms
Description	Choline dehydrogenase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a choline dehydrogenase that localizes to the mitochondrion. Variations in this gene can affect susceptibility to choline deficiency. A few transcript variants have been found for this gene, but the full-length nature of only one has been characterized to date. [provided by RefSeq, Dec 2010]
Chromosome	3
Cytoband	p21.1
Chromosome location (bp)	53812335 - 53846390
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000016391 (version 83.38)
Entrez gene	55349
UniProt	Q8NE62 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NE62
Antibodypedia	CHDH antibodies

PROTEIN BROWSER

CHDH-001	CHDH-002	CHDH-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHDH-001 ENSP00000319851 ENST00000315251	Q8NE62 [Direct mapping] Choline dehydrogenase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0008812 [choline dehydrogenase activity] GO:0016614 [oxidoreductase activity, acting on CH-OH group of donors] GO:0019285 [glycine betaine biosynthetic process from choline] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	594 aa 65.4 kDa	No	0
CHDH-002 ENSP00000419863 ENST00000467802	C9JYW4 [Direct mapping] Choline dehydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016614 [oxidoreductase activity, acting on CH-OH group of donors] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	126 aa 13.6 kDa	No	0
CHDH-003 ENSP00000418273 ENST00000481668	C9J7D8 [Direct mapping] Choline dehydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016614 [oxidoreductase activity, acting on CH-OH group of donors] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	155 aa 16.9 kDa	No	0