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CHDH

GENERAL INFORMATION

Gene name

 CHDH

Gene description

 Choline dehydrogenase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (kidney)
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression with a granular pattern in several tissues, most abundant in renal tubules.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA036633 , HPA058130
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 CHDH

Synonyms

Description

 Choline dehydrogenase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a choline dehydrogenase that localizes to the mitochondrion. Variations in this gene can affect susceptibility to choline deficiency. A few transcript variants have been found for this gene, but the full-length nature of only one has been characterized to date. [provided by RefSeq, Dec 2010]

Chromosome

 3

Cytoband

 p21.1

Chromosome location (bp)

 53812335 - 53846390

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000016391 (version 83.38)

Entrez gene

 55349

UniProt

 Q8NE62 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NE62

Antibodypedia

 CHDH antibodies

PROTEIN BROWSER
CHDH-001
CHDH-002
CHDH-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHDH-001
ENSP00000319851
ENST00000315251
Q8NE62 [Direct mapping]
Choline dehydrogenase, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0008812 [choline dehydrogenase activity]
GO:0016614 [oxidoreductase activity, acting on CH-OH group of donors]
GO:0019285 [glycine betaine biosynthetic process from choline]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
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 594 aa
65.4 kDa 		No 0
CHDH-002
ENSP00000419863
ENST00000467802
C9JYW4 [Direct mapping]
Choline dehydrogenase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016614 [oxidoreductase activity, acting on CH-OH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
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 126 aa
13.6 kDa 		No 0
CHDH-003
ENSP00000418273
ENST00000481668
C9J7D8 [Direct mapping]
Choline dehydrogenase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016614 [oxidoreductase activity, acting on CH-OH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 155 aa
16.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.