Cell atlas - RALBP1 - The Human Protein Atlas

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RALBP1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear membrane
	Vesicles

Human cell
	Cytosol
	Nuclear membrane
	Vesicles

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GENERAL INFORMATION
Gene name	RALBP1
Gene description	RalA binding protein 1
Protein class	Predicted intracellular proteins RAS pathway related proteins Transporters
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nuclear membrane & vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Nuclear membrane (approved), Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA046651
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nuclear membrane & vesicles.

Main location

Cytosol (approved)

Additional location

Nuclear membrane (approved), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046651	A-431	Nuclear membrane
			Vesicles
			Cytosol
	HPA046651	U-2 OS	Cytosol
	HPA046651	U-251 MG	No staining

GENE INFORMATION
Gene name	RALBP1 (HGNC Symbol)
Synonyms	RIP, RIP1, RLIP76
Description	RalA binding protein 1 (HGNC Symbol)
Entrez gene summary	RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]
Chromosome	18
Cytoband	p11.22
Chromosome location (bp)	9475009 - 9538116
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000017797 (version 83.38)
Entrez gene	10928
UniProt	Q15311 (UniProt - Evidence at protein level)
neXtProt	NX_Q15311
Antibodypedia	RALBP1 antibodies

PROTEIN BROWSER

RALBP1-001	RALBP1-002	RALBP1-004	RALBP1-005	RALBP1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RALBP1-001 ENSP00000019317 ENST00000019317	Q15311 [Direct mapping] RalA-binding protein 1 Show all	Transporters Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006810 [transport] GO:0006897 [endocytosis] GO:0006935 [chemotaxis] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0016887 [ATPase activity] GO:0017160 [Ral GTPase binding] GO:0022857 [transmembrane transporter activity] GO:0043087 [regulation of GTPase activity] GO:0043492 [ATPase activity, coupled to movement of substances] GO:0043547 [positive regulation of GTPase activity] GO:0048365 [Rac GTPase binding] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0055085 [transmembrane transport] Show all	655 aa 76.1 kDa	No	0
RALBP1-002 ENSP00000372924 ENST00000383432	Q15311 [Direct mapping] RalA-binding protein 1 Show all	Transporters Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006810 [transport] GO:0006897 [endocytosis] GO:0006935 [chemotaxis] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0016887 [ATPase activity] GO:0017160 [Ral GTPase binding] GO:0022857 [transmembrane transporter activity] GO:0043087 [regulation of GTPase activity] GO:0043492 [ATPase activity, coupled to movement of substances] GO:0043547 [positive regulation of GTPase activity] GO:0048365 [Rac GTPase binding] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0055085 [transmembrane transport] Show all	655 aa 76.1 kDa	No	0
RALBP1-004 ENSP00000462549 ENST00000577221		Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		3 aa 0.4 kDa	No	0
RALBP1-005 ENSP00000411556 ENST00000458039	E7ENF8 [Direct mapping] RalA-binding protein 1 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		207 aa 23.7 kDa	No	0
RALBP1-006 ENSP00000463693 ENST00000585015	J3QLT3 [Direct mapping] RalA-binding protein 1 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		186 aa 21.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.