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RALBP1

GENERAL INFORMATION

Gene name

 RALBP1

Gene description

 RalA binding protein 1

Protein class

 Predicted intracellular proteins
RAS pathway related proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA046651 , CAB046010
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and ovarian cancer (favourable).
Renal cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046651
CAB046010

GENE INFORMATION

Gene name

 RALBP1 (HGNC Symbol)

Synonyms

 RIP, RIP1, RLIP76

Description

 RalA binding protein 1 (HGNC Symbol)

Entrez gene summary

 RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]

Chromosome

 18

Cytoband

 p11.22

Chromosome location (bp)

 9475009 - 9538116

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000017797 (version 83.38)

Entrez gene

 10928

UniProt

 Q15311 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15311

Antibodypedia

 RALBP1 antibodies

PROTEIN BROWSER
RALBP1-001
RALBP1-002
RALBP1-004
RALBP1-005
RALBP1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RALBP1-001
ENSP00000019317
ENST00000019317
Q15311 [Direct mapping]
RalA-binding protein 1
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Transporters
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006810 [transport]
GO:0006897 [endocytosis]
GO:0006935 [chemotaxis]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0017160 [Ral GTPase binding]
GO:0022857 [transmembrane transporter activity]
GO:0043087 [regulation of GTPase activity]
GO:0043492 [ATPase activity, coupled to movement of substances]
GO:0043547 [positive regulation of GTPase activity]
GO:0048365 [Rac GTPase binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0055085 [transmembrane transport]
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 655 aa
76.1 kDa 		No 0
RALBP1-002
ENSP00000372924
ENST00000383432
Q15311 [Direct mapping]
RalA-binding protein 1
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Transporters
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006810 [transport]
GO:0006897 [endocytosis]
GO:0006935 [chemotaxis]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0017160 [Ral GTPase binding]
GO:0022857 [transmembrane transporter activity]
GO:0043087 [regulation of GTPase activity]
GO:0043492 [ATPase activity, coupled to movement of substances]
GO:0043547 [positive regulation of GTPase activity]
GO:0048365 [Rac GTPase binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0055085 [transmembrane transport]
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 655 aa
76.1 kDa 		No 0
RALBP1-004
ENSP00000462549
ENST00000577221
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
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 3 aa
0.4 kDa 		No 0
RALBP1-005
ENSP00000411556
ENST00000458039
E7ENF8 [Direct mapping]
RalA-binding protein 1
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
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 207 aa
23.7 kDa 		No 0
RALBP1-006
ENSP00000463693
ENST00000585015
J3QLT3 [Direct mapping]
RalA-binding protein 1
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
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 186 aa
21.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.