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SLC11A1

GENERAL INFORMATION

Gene name

 SLC11A1

Gene description

 Solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (appendix, lung)
GTEx:Group enriched (lung, spleen)
FANTOM5:Tissue enhanced (lung)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression at variable levels in several tissues, including subsets of immune cells in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Uncertain based on 1 antibody.
HPA029590
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, lung)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lung, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)

GENE INFORMATION

Gene name

 SLC11A1 (HGNC Symbol)

Synonyms

 LSH, NRAMP, NRAMP1

Description

 Solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 218382029 - 218396894

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000018280 (version 83.38)

Entrez gene

 6556

UniProt

 P49279 (UniProt - Evidence at transcript level)

neXtProt

 NX_P49279

Antibodypedia

 SLC11A1 antibodies

PROTEIN BROWSER
SLC11A1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC11A1-001
ENSP00000233202
ENST00000233202
P49279 [Direct mapping]
Natural resistance-associated macrophage protein 1
A0A024R474 [Target identity:100%; Query identity:100%]
Solute carrier family 11 (Proton-coupled divalent metal ion transporters), member 1, isoform CRA_b
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0000060 [protein import into nucleus, translocation]
GO:0001818 [negative regulation of cytokine production]
GO:0001819 [positive regulation of cytokine production]
GO:0002309 [T cell proliferation involved in immune response]
GO:0002369 [T cell cytokine production]
GO:0002606 [positive regulation of dendritic cell antigen processing and presentation]
GO:0002827 [positive regulation of T-helper 1 type immune response]
GO:0005215 [transporter activity]
GO:0005384 [manganese ion transmembrane transporter activity]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006826 [iron ion transport]
GO:0006828 [manganese ion transport]
GO:0006876 [cellular cadmium ion homeostasis]
GO:0006879 [cellular iron ion homeostasis]
GO:0006909 [phagocytosis]
GO:0006954 [inflammatory response]
GO:0007035 [vacuolar acidification]
GO:0009279 [cell outer membrane]
GO:0009617 [response to bacterium]
GO:0010008 [endosome membrane]
GO:0010628 [positive regulation of gene expression]
GO:0015707 [nitrite transport]
GO:0016020 [membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0031902 [late endosome membrane]
GO:0032147 [activation of protein kinase activity]
GO:0032496 [response to lipopolysaccharide]
GO:0032623 [interleukin-2 production]
GO:0032632 [interleukin-3 production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0034341 [response to interferon-gamma]
GO:0042060 [wound healing]
GO:0042116 [macrophage activation]
GO:0042742 [defense response to bacterium]
GO:0042803 [protein homodimerization activity]
GO:0042832 [defense response to protozoan]
GO:0043091 [L-arginine import]
GO:0045342 [MHC class II biosynthetic process]
GO:0045730 [respiratory burst]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046915 [transition metal ion transmembrane transporter activity]
GO:0048002 [antigen processing and presentation of peptide antigen]
GO:0048255 [mRNA stabilization]
GO:0050766 [positive regulation of phagocytosis]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0051139 [metal ion:proton antiporter activity]
GO:0055072 [iron ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0060586 [multicellular organismal iron ion homeostasis]
GO:0070574 [cadmium ion transmembrane transport]
GO:0070821 [tertiary granule membrane]
GO:0070839 [divalent metal ion export]
GO:0071421 [manganese ion transmembrane transport]
GO:0090382 [phagosome maturation]
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 550 aa
59.9 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.