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AGPS

GENERAL INFORMATION

Gene name

 AGPS

Gene description

 Alkylglycerone phosphate synthase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous granular cytoplasmic expression, most abundant in glandular cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA030209 , HPA030210 , HPA030211
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), pancreatic cancer (unfavourable) and renal cancer (favourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA030209
HPA030210
HPA030211

GENE INFORMATION

Gene name

 AGPS (HGNC Symbol)

Synonyms

 ADAP-S, ADAS, ADHAPS, ADPS, ALDHPSY

Description

 Alkylglycerone phosphate synthase (HGNC Symbol)

Entrez gene summary

 This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q31.2

Chromosome location (bp)

 177392644 - 177543836

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000018510 (version 83.38)

Entrez gene

 8540

UniProt

 O00116 (UniProt - Evidence at protein level)

neXtProt

 NX_O00116

Antibodypedia

 AGPS antibodies

PROTEIN BROWSER
AGPS-001
AGPS-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AGPS-001
ENSP00000264167
ENST00000264167
O00116 [Direct mapping]
Alkyldihydroxyacetonephosphate synthase, peroxisomal
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0005782 [peroxisomal matrix]
GO:0008609 [alkylglycerone-phosphate synthase activity]
GO:0008610 [lipid biosynthetic process]
GO:0008611 [ether lipid biosynthetic process]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016614 [oxidoreductase activity, acting on CH-OH group of donors]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
GO:0071949 [FAD binding]
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 658 aa
72.9 kDa 		Yes 0
AGPS-002
ENSP00000386688
ENST00000409888
B8ZZ81 [Direct mapping]
Alkyldihydroxyacetonephosphate synthase, peroxisomal
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008609 [alkylglycerone-phosphate synthase activity]
GO:0008610 [lipid biosynthetic process]
GO:0050660 [flavin adenine dinucleotide binding]
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 189 aa
20.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.