Expression of PHLDB1 in cancer - Summary - The Human Protein Atlas

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PHLDB1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PHLDB1
Gene description	Pleckstrin homology-like domain, family B, member 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA037959 , HPA038448
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037959	HPA038448

GENE INFORMATION
Gene name	PHLDB1 (HGNC Symbol)
Synonyms	FLJ00141, KIAA0638, LL5a
Description	Pleckstrin homology-like domain, family B, member 1 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	118606440 - 118658038
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000019144 (version 83.38)
Entrez gene	23187
UniProt	Q86UU1 (UniProt - Evidence at protein level)
neXtProt	NX_Q86UU1
Antibodypedia	PHLDB1 antibodies

PROTEIN BROWSER

PHLDB1-001	PHLDB1-019	PHLDB1-020	PHLDB1-039	PHLDB1-201	PHLDB1-202	PHLDB1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PHLDB1-001 ENSP00000354498 ENST00000361417	Q86UU1 [Direct mapping] Pleckstrin homology-like domain family B member 1 A0A024R3H6 [Target identity:100%; Query identity:100%] Pleckstrin homology-like domain, family B, member 1, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0010470 [regulation of gastrulation] GO:0010717 [regulation of epithelial to mesenchymal transition] GO:0045180 [basal cortex] GO:0070507 [regulation of microtubule cytoskeleton organization] GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis] Show all	1377 aa 151.2 kDa	No	0
PHLDB1-019 ENSP00000482728 ENST00000534140	A0A087WZL0 [Direct mapping] Pleckstrin homology-like domain family B member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		641 aa 73.1 kDa	No	0
PHLDB1-020 ENSP00000348359 ENST00000356063	Q86UU1 [Direct mapping] Pleckstrin homology-like domain family B member 1 A0A024R3F4 [Target identity:100%; Query identity:100%] Pleckstrin homology-like domain, family B, member 1, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0010470 [regulation of gastrulation] GO:0010717 [regulation of epithelial to mesenchymal transition] GO:0045180 [basal cortex] GO:0070507 [regulation of microtubule cytoskeleton organization] GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis] Show all	1319 aa 144.7 kDa	No	0
PHLDB1-039 ENSP00000478254 ENST00000532639	A0A087WTZ7 [Direct mapping] Pleckstrin homology-like domain family B member 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	209 aa 22 kDa	No	0
PHLDB1-201 ENSP00000481393 ENST00000530708	A0A087WXY7 [Direct mapping] Pleckstrin homology-like domain family B member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	247 aa 25.9 kDa	No	0
PHLDB1-202 ENSP00000469820 ENST00000600882	Q86UU1 [Direct mapping] Pleckstrin homology-like domain family B member 1 A0A024R3H6 [Target identity:100%; Query identity:100%] Pleckstrin homology-like domain, family B, member 1, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0010470 [regulation of gastrulation] GO:0010717 [regulation of epithelial to mesenchymal transition] GO:0045180 [basal cortex] GO:0070507 [regulation of microtubule cytoskeleton organization] GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis] Show all	1377 aa 151.2 kDa	No	0
PHLDB1-203 ENSP00000470046 ENST00000601898	Q96C94 [Direct mapping] PHLDB1 protein; Pleckstrin homology-like domain family B member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		101 aa 11.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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