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PHLDB1

GENERAL INFORMATION

Gene name

 PHLDB1

Gene description

 Pleckstrin homology-like domain, family B, member 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA037959 , HPA038448
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PHLDB1 (HGNC Symbol)

Synonyms

 FLJ00141, KIAA0638, LL5a

Description

 Pleckstrin homology-like domain, family B, member 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 118606440 - 118658038

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000019144 (version 83.38)

Entrez gene

 23187

UniProt

 Q86UU1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86UU1

Antibodypedia

 PHLDB1 antibodies

PROTEIN BROWSER
PHLDB1-001
PHLDB1-019
PHLDB1-020
PHLDB1-039
PHLDB1-201
PHLDB1-202
PHLDB1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PHLDB1-001
ENSP00000354498
ENST00000361417
Q86UU1 [Direct mapping]
Pleckstrin homology-like domain family B member 1
A0A024R3H6 [Target identity:100%; Query identity:100%]
Pleckstrin homology-like domain, family B, member 1, isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0010470 [regulation of gastrulation]
GO:0010717 [regulation of epithelial to mesenchymal transition]
GO:0045180 [basal cortex]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis]
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 1377 aa
151.2 kDa 		No 0
PHLDB1-019
ENSP00000482728
ENST00000534140
A0A087WZL0 [Direct mapping]
Pleckstrin homology-like domain family B member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 641 aa
73.1 kDa 		No 0
PHLDB1-020
ENSP00000348359
ENST00000356063
Q86UU1 [Direct mapping]
Pleckstrin homology-like domain family B member 1
A0A024R3F4 [Target identity:100%; Query identity:100%]
Pleckstrin homology-like domain, family B, member 1, isoform CRA_c
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0010470 [regulation of gastrulation]
GO:0010717 [regulation of epithelial to mesenchymal transition]
GO:0045180 [basal cortex]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis]
Show all
 1319 aa
144.7 kDa 		No 0
PHLDB1-039
ENSP00000478254
ENST00000532639
A0A087WTZ7 [Direct mapping]
Pleckstrin homology-like domain family B member 1
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 209 aa
22 kDa 		No 0
PHLDB1-201
ENSP00000481393
ENST00000530708
A0A087WXY7 [Direct mapping]
Pleckstrin homology-like domain family B member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 247 aa
25.9 kDa 		No 0
PHLDB1-202
ENSP00000469820
ENST00000600882
Q86UU1 [Direct mapping]
Pleckstrin homology-like domain family B member 1
A0A024R3H6 [Target identity:100%; Query identity:100%]
Pleckstrin homology-like domain, family B, member 1, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0010470 [regulation of gastrulation]
GO:0010717 [regulation of epithelial to mesenchymal transition]
GO:0045180 [basal cortex]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis]
Show all
 1377 aa
151.2 kDa 		No 0
PHLDB1-203
ENSP00000470046
ENST00000601898
Q96C94 [Direct mapping]
PHLDB1 protein; Pleckstrin homology-like domain family B member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 101 aa
11.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.