Tissue expression of NCDN - Summary - The Human Protein Atlas

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NCDN

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TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA
MOUSE BRAIN

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	NCDN
Gene description	Neurochondrin
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

High cytoplasmic expression in CNS.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA023676
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	NCDN (HGNC Symbol)
Synonyms	NCDN-1, NCDN-2
Description	Neurochondrin (HGNC Symbol)
Entrez gene summary	This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p34.3
Chromosome location (bp)	35557473 - 35567274
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000020129 (version 83.38)
Entrez gene	23154
UniProt	Q9UBB6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBB6
Antibodypedia	NCDN antibodies

PROTEIN BROWSER

NCDN-001	NCDN-002	NCDN-003	NCDN-005	NCDN-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NCDN-001 ENSP00000348394 ENST00000356090	Q9UBB6 [Direct mapping] Neurochondrin Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0030425 [dendrite] GO:0031175 [neuron projection development] GO:0043025 [neuronal cell body] Show all	729 aa 78.9 kDa	No	0
NCDN-002 ENSP00000362350 ENST00000373253	Q9UBB6 [Direct mapping] Neurochondrin Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0030425 [dendrite] GO:0031175 [neuron projection development] GO:0043025 [neuronal cell body] Show all	712 aa 77.2 kDa	No	0
NCDN-003 ENSP00000362340 ENST00000373243	Q9UBB6 [Direct mapping] Neurochondrin Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0030425 [dendrite] GO:0031175 [neuron projection development] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0045453 [bone resorption] GO:0048168 [regulation of neuronal synaptic plasticity] Show all	729 aa 78.9 kDa	No	0
NCDN-005 ENSP00000406511 ENST00000437806	C9J5H8 [Direct mapping] Neurochondrin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		244 aa 26.4 kDa	No	0
NCDN-006 ENSP00000407339 ENST00000423723	H7C2R2 [Direct mapping] Neurochondrin Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		193 aa 20.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.