Expression of ADGRA2 in cancer - Summary - The Human Protein Atlas

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ADGRA2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADGRA2
Gene description	Adhesion G protein-coupled receptor A2
Protein class	G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, BJ, BJ hTERT+)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending retesting. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA012393
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012393

GENE INFORMATION
Gene name	ADGRA2 (HGNC Symbol)
Synonyms	DKFZp434C211, DKFZp434J0911, FLJ14390, GPR124, KIAA1531, TEM5
Description	Adhesion G protein-coupled receptor A2 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	p11.23
Chromosome location (bp)	37784191 - 37844896
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000020181 (version 83.38)
Entrez gene	25960
UniProt	Q96PE1 (UniProt - Evidence at protein level)
neXtProt	NX_Q96PE1
Antibodypedia	ADGRA2 antibodies

PROTEIN BROWSER

ADGRA2-001	ADGRA2-002	ADGRA2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRA2-001 ENSP00000406367 ENST00000412232	Q96PE1 [Direct mapping] G-protein coupled receptor 124 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0002040 [sprouting angiogenesis] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007417 [central nervous system development] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043542 [endothelial cell migration] GO:0045765 [regulation of angiogenesis] GO:0050920 [regulation of chemotaxis] GO:0090210 [regulation of establishment of blood-brain barrier] GO:1900747 [negative regulation of vascular endothelial growth factor signaling pathway] Show all	1338 aa 142.6 kDa	Yes	7
ADGRA2-002 ENSP00000323508 ENST00000315215	Q96PE1 [Direct mapping] G-protein coupled receptor 124 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002040 [sprouting angiogenesis] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007417 [central nervous system development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043542 [endothelial cell migration] GO:0045765 [regulation of angiogenesis] GO:0050920 [regulation of chemotaxis] Show all	1121 aa 119.9 kDa	Yes	7
ADGRA2-004 ENSP00000400860 ENST00000428068	H7C1L1 [Direct mapping] Protein ADGRA2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	190 aa 20.8 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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