Expression of SERPINB1 in cancer - Summary - The Human Protein Atlas

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SERPINB1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SERPINB1
Gene description	Serpin peptidase inhibitor, clade B (ovalbumin), member 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in subsets of immune cells in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 2 antibodies. HPA018871 , HPA052642
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018871	HPA052642

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	A few cases of colorectal and pancreatic cancers showed weak to moderate cytoplasmic and nuclear staining. Most remaining cancer tissues were negative.

GENE INFORMATION
Gene name	SERPINB1 (HGNC Symbol)
Synonyms	anti-elastase, EI, ELANH2, PI2
Description	Serpin peptidase inhibitor, clade B (ovalbumin), member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Chromosome	6
Cytoband	p25.2
Chromosome location (bp)	2832332 - 2842006
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000021355 (version 83.38)
Entrez gene	1992
UniProt	P30740 (UniProt - Evidence at protein level)
neXtProt	NX_P30740
Antibodypedia	SERPINB1 antibodies

PROTEIN BROWSER

SERPINB1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINB1-003 ENSP00000370115 ENST00000380739	P30740 [Direct mapping] Leukocyte elastase inhibitor V9HWH1 [Target identity:100%; Query identity:100%] Epididymis luminal protein 57; Serpin peptidase inhibitor, clade B (Ovalbumin), member 1, isoform CRA_a Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0070062 [extracellular exosome] Show all	379 aa 42.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.