Expression of BIRC3 in cancer - Summary

GENERAL INFORMATION
Gene nameⁱ Gene name according to HGNC.	BIRC3
Gene descriptionⁱ Gene description according to HGNC.	Baculoviral IAP repeat containing 3
Protein classⁱ Protein class the gene product belongs to according to selected gene lists. List of protein classes.	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localizationⁱ Protein localization predicted from several bioinformatic algorithms. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcribed from this gene as defined by Ensembl.	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryⁱ

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CAPAN-2, Daudi, HDLM-2)
HPA (normal tissue):	Tissue enhanced (lymph node)

Protein evidenceⁱ

Evidence at protein level

Protein expression
normal tissueⁱ

Expression in several tissues, most abundant in subsets of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability descriptionⁱ Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.	Antibody staining mainly consistent with RNA expression data.
Reliability scoreⁱ Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data. Read more	Supported based on 1 antibody. HPA002317
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PROGNOSTIC SUMMARYⁱ Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Prognostic marker in renal cancer (unfavourable), pancreatic cancer (unfavourable), breast cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Breast cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEWⁱ

TCGA datasetⁱ
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more

RNA cancer category: Expressed in all

PROTEIN EXPRESSIONⁱ

STAINING SUMMARYⁱ

HPA002317

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	BIRC3 (HGNC Symbol)
Synonyms	API2, c-IAP2, cIAP2, hiap-1, MALT2, MIHC, RNF49
Description	Baculoviral IAP repeat containing 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]
Chromosome	11
Cytoband	q22.2
Chromosome location (bp)	102317450 - 102339403
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000023445 (version 83.38)
Entrez gene	330
UniProt	Q13489 (UniProt - Evidence at protein level)
neXtProt	NX_Q13489
Antibodypedia	BIRC3 antibodies

PROTEIN BROWSERⁱ

BIRC3-001	BIRC3-002	BIRC3-006	BIRC3-201

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BIRC3-001 ENSP00000432907 ENST00000532808	Q13489 [Direct mapping] Baculoviral IAP repeat-containing protein 3 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007166 [cell surface receptor signaling pathway] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0008270 [zinc ion binding] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0010939 [regulation of necrotic cell death] GO:0012501 [programmed cell death] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0031398 [positive regulation of protein ubiquitination] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034121 [regulation of toll-like receptor signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038061 [NIK/NF-kappaB signaling] GO:0039535 [regulation of RIG-I signaling pathway] GO:0042981 [regulation of apoptotic process] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0045088 [regulation of innate immune response] GO:0050727 [regulation of inflammatory response] GO:0060544 [regulation of necroptotic process] GO:0060546 [negative regulation of necroptotic process] GO:0070266 [necroptotic process] GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway] GO:0097300 [programmed necrotic cell death] GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process] GO:2000116 [regulation of cysteine-type endopeptidase activity] Show all	604 aa 68.4 kDa	No	0
BIRC3-002 ENSP00000263464 ENST00000263464	Q13489 [Direct mapping] Baculoviral IAP repeat-containing protein 3 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007166 [cell surface receptor signaling pathway] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007283 [spermatogenesis] GO:0008270 [zinc ion binding] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0010939 [regulation of necrotic cell death] GO:0012501 [programmed cell death] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0031398 [positive regulation of protein ubiquitination] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034121 [regulation of toll-like receptor signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038061 [NIK/NF-kappaB signaling] GO:0039535 [regulation of RIG-I signaling pathway] GO:0042981 [regulation of apoptotic process] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045087 [innate immune response] GO:0045088 [regulation of innate immune response] GO:0045121 [membrane raft] GO:0050727 [regulation of inflammatory response] GO:0051291 [protein heterooligomerization] GO:0060544 [regulation of necroptotic process] GO:0060546 [negative regulation of necroptotic process] GO:0070266 [necroptotic process] GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway] GO:0097300 [programmed necrotic cell death] GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process] GO:2000116 [regulation of cysteine-type endopeptidase activity] Show all	604 aa 68.4 kDa	No	0
BIRC3-006 ENSP00000431718 ENST00000527309	H0YCJ5 [Direct mapping] Baculoviral IAP repeat-containing protein 3 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0060546 [negative regulation of necroptotic process] GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process] Show all	183 aa 20.7 kDa	No	0
BIRC3-201 ENSP00000481903 ENST00000615299	Q13489 [Direct mapping] Baculoviral IAP repeat-containing protein 3 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007166 [cell surface receptor signaling pathway] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0008270 [zinc ion binding] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0010939 [regulation of necrotic cell death] GO:0012501 [programmed cell death] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0031398 [positive regulation of protein ubiquitination] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034121 [regulation of toll-like receptor signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038061 [NIK/NF-kappaB signaling] GO:0039535 [regulation of RIG-I signaling pathway] GO:0042981 [regulation of apoptotic process] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0045088 [regulation of innate immune response] GO:0050727 [regulation of inflammatory response] GO:0060544 [regulation of necroptotic process] GO:0060546 [negative regulation of necroptotic process] GO:0070266 [necroptotic process] GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway] GO:0097300 [programmed necrotic cell death] GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process] GO:2000116 [regulation of cysteine-type endopeptidase activity] Show all	604 aa 68.4 kDa	No	0