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BIRC3

GENERAL INFORMATION

Gene name

 BIRC3

Gene description

 Baculoviral IAP repeat containing 3

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CAPAN-2, Daudi, HDLM-2)
HPA (normal tissue):Tissue enhanced (lymph node)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expression in several tissues, most abundant in subsets of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA002317
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), pancreatic cancer (unfavourable), breast cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Breast cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002317

GENE INFORMATION

Gene name

 BIRC3 (HGNC Symbol)

Synonyms

 API2, c-IAP2, cIAP2, hiap-1, MALT2, MIHC, RNF49

Description

 Baculoviral IAP repeat containing 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 q22.2

Chromosome location (bp)

 102317450 - 102339403

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000023445 (version 83.38)

Entrez gene

 330

UniProt

 Q13489 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13489

Antibodypedia

 BIRC3 antibodies

PROTEIN BROWSER
BIRC3-001
BIRC3-002
BIRC3-006
BIRC3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BIRC3-001
ENSP00000432907
ENST00000532808
Q13489 [Direct mapping]
Baculoviral IAP repeat-containing protein 3
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008270 [zinc ion binding]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034121 [regulation of toll-like receptor signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0039535 [regulation of RIG-I signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0060544 [regulation of necroptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
GO:2000116 [regulation of cysteine-type endopeptidase activity]
Show all
 604 aa
68.4 kDa 		No 0
BIRC3-002
ENSP00000263464
ENST00000263464
Q13489 [Direct mapping]
Baculoviral IAP repeat-containing protein 3
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007283 [spermatogenesis]
GO:0008270 [zinc ion binding]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034121 [regulation of toll-like receptor signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0039535 [regulation of RIG-I signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045121 [membrane raft]
GO:0050727 [regulation of inflammatory response]
GO:0051291 [protein heterooligomerization]
GO:0060544 [regulation of necroptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
GO:2000116 [regulation of cysteine-type endopeptidase activity]
Show all
 604 aa
68.4 kDa 		No 0
BIRC3-006
ENSP00000431718
ENST00000527309
H0YCJ5 [Direct mapping]
Baculoviral IAP repeat-containing protein 3
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 183 aa
20.7 kDa 		No 0
BIRC3-201
ENSP00000481903
ENST00000615299
Q13489 [Direct mapping]
Baculoviral IAP repeat-containing protein 3
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008270 [zinc ion binding]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034121 [regulation of toll-like receptor signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0039535 [regulation of RIG-I signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0060544 [regulation of necroptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
GO:2000116 [regulation of cysteine-type endopeptidase activity]
Show all
 604 aa
68.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.