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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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BIRC3
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

BIRC3

Gene description

Baculoviral IAP repeat containing 3

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CAPAN-2, Daudi, HDLM-2)
HPA (normal tissue):Tissue enhanced (lymph node)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in several tissues, most abundant in subsets of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA002317
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), pancreatic cancer (unfavourable), breast cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Breast cancer p<0.001
Colorectal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA002317

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells were in general weakly stained or negative. Moderate nuclear staining was observed in a few cases of malignant gliomas, malignant lymphomas and skin cancer.

GENE INFORMATION

Gene name

BIRC3 (HGNC Symbol)

Synonyms

API2, c-IAP2, cIAP2, hiap-1, MALT2, MIHC, RNF49

Description

Baculoviral IAP repeat containing 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]

Chromosome

11

Cytoband

q22.2

Chromosome location (bp)

102317450 - 102339403

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000023445 (version 83.38)

Entrez gene

330

UniProt

Q13489 (UniProt - Evidence at protein level)

neXtProt

NX_Q13489

Antibodypedia

BIRC3 antibodies

PROTEIN BROWSER

BIRC3-001
BIRC3-002
BIRC3-006
BIRC3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BIRC3-001
ENSP00000432907
ENST00000532808
Q13489 [Direct mapping]
Baculoviral IAP repeat-containing protein 3
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008270 [zinc ion binding]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034121 [regulation of toll-like receptor signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0039535 [regulation of RIG-I signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0060544 [regulation of necroptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
GO:2000116 [regulation of cysteine-type endopeptidase activity]
Show all
604 aa
68.4 kDa
No 0
BIRC3-002
ENSP00000263464
ENST00000263464
Q13489 [Direct mapping]
Baculoviral IAP repeat-containing protein 3
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007283 [spermatogenesis]
GO:0008270 [zinc ion binding]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034121 [regulation of toll-like receptor signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0039535 [regulation of RIG-I signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045121 [membrane raft]
GO:0050727 [regulation of inflammatory response]
GO:0051291 [protein heterooligomerization]
GO:0060544 [regulation of necroptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
GO:2000116 [regulation of cysteine-type endopeptidase activity]
Show all
604 aa
68.4 kDa
No 0
BIRC3-006
ENSP00000431718
ENST00000527309
H0YCJ5 [Direct mapping]
Baculoviral IAP repeat-containing protein 3
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
183 aa
20.7 kDa
No 0
BIRC3-201
ENSP00000481903
ENST00000615299
Q13489 [Direct mapping]
Baculoviral IAP repeat-containing protein 3
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008270 [zinc ion binding]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034121 [regulation of toll-like receptor signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0039535 [regulation of RIG-I signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0060544 [regulation of necroptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
GO:2000116 [regulation of cysteine-type endopeptidase activity]
Show all
604 aa
68.4 kDa
No 0

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The Human Protein Atlas project is funded
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