Malignant cells were in general weakly stained or negative. Moderate nuclear staining was observed in a few cases of malignant gliomas, malignant lymphomas and skin cancer.
BIRC3 (HGNC Symbol)
API2, c-IAP2, cIAP2, hiap-1, MALT2, MIHC, RNF49
Baculoviral IAP repeat containing 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]
Q13489 [Direct mapping] Baculoviral IAP repeat-containing protein 3
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)