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AKAP11

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GENERAL INFORMATION

Gene name

 AKAP11

Gene description

 A kinase (PRKA) anchor protein 11

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoli, plasma membrane & cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli (approved), Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA039089
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoli, plasma membrane & cytosol.

Main location

 Nucleoli (approved), Plasma membrane (approved), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA039089 A-431 Nucleoli
Plasma membrane
Cytosol
HPA039089 U-2 OS Nucleoli
Plasma membrane
Cytosol
HPA039089 U-251 MG Nucleoli
Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 AKAP11 (HGNC Symbol)

Synonyms

 AKAP220, DKFZp781I12161, FLJ11304, KIAA0629, PPP1R44, PRKA11

Description

 A kinase (PRKA) anchor protein 11 (HGNC Symbol)

Entrez gene summary

 The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q14.11

Chromosome location (bp)

 42272153 - 42323267

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000023516 (version 83.38)

Entrez gene

 11215

UniProt

 Q9UKA4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKA4

Antibodypedia

 AKAP11 antibodies

PROTEIN BROWSER
AKAP11-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKAP11-001
ENSP00000025301
ENST00000025301
Q9UKA4 [Direct mapping]
A-kinase anchor protein 11
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0005777 [peroxisome]
GO:0005815 [microtubule organizing center]
GO:0008157 [protein phosphatase 1 binding]
GO:0010738 [regulation of protein kinase A signaling]
GO:0032947 [protein complex scaffold]
GO:0034236 [protein kinase A catalytic subunit binding]
GO:0034237 [protein kinase A regulatory subunit binding]
GO:0035556 [intracellular signal transduction]
GO:0043234 [protein complex]
GO:0051018 [protein kinase A binding]
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 1901 aa
210.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.