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AKAP11

GENERAL INFORMATION

Gene name

 AKAP11

Gene description

 A kinase (PRKA) anchor protein 11

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA039089
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable).
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039089

GENE INFORMATION

Gene name

 AKAP11 (HGNC Symbol)

Synonyms

 AKAP220, DKFZp781I12161, FLJ11304, KIAA0629, PPP1R44, PRKA11

Description

 A kinase (PRKA) anchor protein 11 (HGNC Symbol)

Entrez gene summary

 The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q14.11

Chromosome location (bp)

 42272153 - 42323267

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000023516 (version 83.38)

Entrez gene

 11215

UniProt

 Q9UKA4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKA4

Antibodypedia

 AKAP11 antibodies

PROTEIN BROWSER
AKAP11-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKAP11-001
ENSP00000025301
ENST00000025301
Q9UKA4 [Direct mapping]
A-kinase anchor protein 11
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0005777 [peroxisome]
GO:0005815 [microtubule organizing center]
GO:0008157 [protein phosphatase 1 binding]
GO:0010738 [regulation of protein kinase A signaling]
GO:0032947 [protein complex scaffold]
GO:0034236 [protein kinase A catalytic subunit binding]
GO:0034237 [protein kinase A regulatory subunit binding]
GO:0035556 [intracellular signal transduction]
GO:0043234 [protein complex]
GO:0051018 [protein kinase A binding]
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 1901 aa
210.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.