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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ABCC2
  • TISSUE

  • CELL

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ABCC2

Gene description

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Protein class

Cancer-related genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (liver cancer)
HPA (cell line):Cell line enhanced (A549, Hep G2)
HPA (normal tissue):Group enriched (duodenum, gallbladder, kidney, liver, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High membranous staining in liver, kidney and gallbladder.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Approved based on 2 antibodies.
HPA004860 , CAB037271
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA004860
CAB037271

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate granular positivity was observed in a few cases in most cancers, while several melanomas, liver and prostate cancers showed moderate positivity.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A few cases of thyroid, lymphomas, urothelial, renal, stomach, pancreatic and liver cancers displayed moderate cytoplasmic and nuclear positivity. Remaining cancers were weakly stained or negative.

GENE INFORMATION

Gene name

ABCC2 (HGNC Symbol)

Synonyms

CMOAT, cMRP, DJS, MRP2

Description

ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q24.2

Chromosome location (bp)

99782732 - 99852192

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000023839 (version 83.38)

Entrez gene

1244

UniProt

Q92887 (UniProt - Evidence at protein level)

neXtProt

NX_Q92887

Antibodypedia

ABCC2 antibodies

PROTEIN BROWSER

ABCC2-001
ABCC2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCC2-001
ENSP00000359478
ENST00000370449
Q92887 [Direct mapping]
Canalicular multispecific organic anion transporter 1
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Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006855 [drug transmembrane transport]
GO:0006979 [response to oxidative stress]
GO:0008152 [metabolic process]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0009408 [response to heat]
GO:0009986 [cell surface]
GO:0015732 [prostaglandin transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016887 [ATPase activity]
GO:0019904 [protein domain specific binding]
GO:0030644 [cellular chloride ion homeostasis]
GO:0031427 [response to methotrexate]
GO:0042493 [response to drug]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0043627 [response to estrogen]
GO:0046685 [response to arsenic-containing substance]
GO:0048545 [response to steroid hormone]
GO:0055085 [transmembrane transport]
GO:0070327 [thyroid hormone transport]
Show all
1545 aa
174.2 kDa
No >9
ABCC2-002
ENSP00000359463
ENST00000370434
Q5TCZ5 [Direct mapping]
Canalicular multispecific organic anion transporter 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005887 [integral component of plasma membrane]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
293 aa
33.8 kDa
No 5

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