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ABCC2

GENERAL INFORMATION

Gene name

 ABCC2

Gene description

 ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Protein class

 Cancer-related genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (duodenum, gallbladder, kidney, liver, small intestine)
GTEx:Tissue enhanced (liver)
FANTOM5:Group enriched (colon, gallbladder, kidney, liver, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 High membranous staining in liver, kidney and gallbladder.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA004860 , CAB037271
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (duodenum, gallbladder, kidney, liver, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, gallbladder, kidney, liver, small intestine)

GENE INFORMATION

Gene name

 ABCC2 (HGNC Symbol)

Synonyms

 CMOAT, cMRP, DJS, MRP2

Description

 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q24.2

Chromosome location (bp)

 99782732 - 99852192

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000023839 (version 83.38)

Entrez gene

 1244

UniProt

 Q92887 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92887

Antibodypedia

 ABCC2 antibodies

PROTEIN BROWSER
ABCC2-001
ABCC2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCC2-001
ENSP00000359478
ENST00000370449
Q92887 [Direct mapping]
Canalicular multispecific organic anion transporter 1
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Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006855 [drug transmembrane transport]
GO:0006979 [response to oxidative stress]
GO:0008152 [metabolic process]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0009408 [response to heat]
GO:0009986 [cell surface]
GO:0015732 [prostaglandin transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016887 [ATPase activity]
GO:0019904 [protein domain specific binding]
GO:0030644 [cellular chloride ion homeostasis]
GO:0031427 [response to methotrexate]
GO:0042493 [response to drug]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0043627 [response to estrogen]
GO:0046685 [response to arsenic-containing substance]
GO:0048545 [response to steroid hormone]
GO:0055085 [transmembrane transport]
GO:0070327 [thyroid hormone transport]
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 1545 aa
174.2 kDa 		No >9
ABCC2-002
ENSP00000359463
ENST00000370434
Q5TCZ5 [Direct mapping]
Canalicular multispecific organic anion transporter 1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005887 [integral component of plasma membrane]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
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 293 aa
33.8 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.