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Most cancers displayed moderate positivity. Strong staining was observed in prostate cancers and cases of urothelial, breast, thyroid, endometrial and squamous cell carcinomas. A majority of melanomas, skin and pancreatic cancers were negative.
Moderate cytoplasmic immunoreactivity was observed in several cases of lymphomas, melanomas, colorectal, cervical, endometrial and urothelial cancers. Additional nuclear staining was observed in squamous cell carcinomas, colorectal and urothelial cancers. A few cases of liver cancers displayed strong staining. Other cancer tissues were in general weakly stained or negative.
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)