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GCLM

GENERAL INFORMATION

Gene name

 GCLM

Gene description

 Glutamate-cysteine ligase, modifier subunit

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 3 antibodies.
HPA023696 , CAB009568 , CAB040554
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GCLM (HGNC Symbol)

Synonyms

 GLCLR

Description

 Glutamate-cysteine ligase, modifier subunit (HGNC Symbol)

Entrez gene summary

 Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Chromosome

 1

Cytoband

 p22.1

Chromosome location (bp)

 93885205 - 93909456

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000023909 (version 83.38)

Entrez gene

 2730

UniProt

 P48507 (UniProt - Evidence at protein level)

neXtProt

 NX_P48507

Antibodypedia

 GCLM antibodies

PROTEIN BROWSER
GCLM-001
GCLM-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GCLM-001
ENSP00000359258
ENST00000370238
P48507 [Direct mapping]
Glutamate--cysteine ligase regulatory subunit
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000096 [sulfur amino acid metabolic process]
GO:0004357 [glutamate-cysteine ligase activity]
GO:0005829 [cytosol]
GO:0006534 [cysteine metabolic process]
GO:0006536 [glutamate metabolic process]
GO:0006749 [glutathione metabolic process]
GO:0006750 [glutathione biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0006979 [response to oxidative stress]
GO:0008637 [apoptotic mitochondrial changes]
GO:0017109 [glutamate-cysteine ligase complex]
GO:0030234 [enzyme regulator activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035226 [glutamate-cysteine ligase catalytic subunit binding]
GO:0035229 [positive regulation of glutamate-cysteine ligase activity]
GO:0042493 [response to drug]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
GO:0050880 [regulation of blood vessel size]
GO:0051409 [response to nitrosative stress]
GO:0051900 [regulation of mitochondrial depolarization]
GO:1901687 [glutathione derivative biosynthetic process]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 274 aa
30.7 kDa 		No 0
GCLM-201
ENSP00000484507
ENST00000615724
P48507 [Direct mapping]
Glutamate--cysteine ligase regulatory subunit
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000096 [sulfur amino acid metabolic process]
GO:0004357 [glutamate-cysteine ligase activity]
GO:0005829 [cytosol]
GO:0006536 [glutamate metabolic process]
GO:0006750 [glutathione biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0006979 [response to oxidative stress]
GO:0017109 [glutamate-cysteine ligase complex]
GO:0030234 [enzyme regulator activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035226 [glutamate-cysteine ligase catalytic subunit binding]
GO:0035229 [positive regulation of glutamate-cysteine ligase activity]
GO:0042493 [response to drug]
GO:0044281 [small molecule metabolic process]
GO:0050880 [regulation of blood vessel size]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
 252 aa
28.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.