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NR1H3

GENERAL INFORMATION

Gene name

 NR1H3

Gene description

 Nuclear receptor subfamily 1, group H, member 3

Protein class

 Nuclear receptors
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 17
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA036443 , CAB037109
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (favourable), endometrial cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Endometrial cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036443
CAB037109

GENE INFORMATION

Gene name

 NR1H3 (HGNC Symbol)

Synonyms

 LXR-a, RLD-1

Description

 Nuclear receptor subfamily 1, group H, member 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 11

Cytoband

 p11.2

Chromosome location (bp)

 47248300 - 47269032

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000025434 (version 83.38)

Entrez gene

 10062

UniProt

 Q13133 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13133

Antibodypedia

 NR1H3 antibodies

PROTEIN BROWSER
«
NR1H3-001
NR1H3-002
NR1H3-003
NR1H3-006
NR1H3-007
NR1H3-010
NR1H3-011
NR1H3-012
NR1H3-013
NR1H3-016
NR1H3-017
NR1H3-023
NR1H3-030
NR1H3-031
NR1H3-032
NR1H3-037
NR1H3-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NR1H3-001
ENSP00000420656
ENST00000467728
Q13133 [Direct mapping]
Oxysterols receptor LXR-alpha
F1D8N1 [Target identity:100%; Query identity:100%]
Liver X nuclear receptor alpha variant 1
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0010870 [positive regulation of receptor biosynthetic process]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032369 [negative regulation of lipid transport]
GO:0032376 [positive regulation of cholesterol transport]
GO:0032570 [response to progesterone]
GO:0032810 [sterol response element binding]
GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway]
GO:0042632 [cholesterol homeostasis]
GO:0042752 [regulation of circadian rhythm]
GO:0043031 [negative regulation of macrophage activation]
GO:0043235 [receptor complex]
GO:0043277 [apoptotic cell clearance]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048550 [negative regulation of pinocytosis]
GO:0050728 [negative regulation of inflammatory response]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0055088 [lipid homeostasis]
GO:0055092 [sterol homeostasis]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0070328 [triglyceride homeostasis]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0090188 [negative regulation of pancreatic juice secretion]
GO:0090341 [negative regulation of secretion of lysosomal enzymes]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000188 [regulation of cholesterol homeostasis]
GO:2000189 [positive regulation of cholesterol homeostasis]
Show all
 447 aa
50.4 kDa 		No 0
NR1H3-002
ENSP00000385801
ENST00000407404
Q13133 [Direct mapping]
Oxysterols receptor LXR-alpha
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0010870 [positive regulation of receptor biosynthetic process]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032369 [negative regulation of lipid transport]
GO:0032376 [positive regulation of cholesterol transport]
GO:0032570 [response to progesterone]
GO:0032810 [sterol response element binding]
GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway]
GO:0042632 [cholesterol homeostasis]
GO:0042752 [regulation of circadian rhythm]
GO:0043031 [negative regulation of macrophage activation]
GO:0043235 [receptor complex]
GO:0043277 [apoptotic cell clearance]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048550 [negative regulation of pinocytosis]
GO:0050728 [negative regulation of inflammatory response]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0055088 [lipid homeostasis]
GO:0055092 [sterol homeostasis]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0070328 [triglyceride homeostasis]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0090188 [negative regulation of pancreatic juice secretion]
GO:0090341 [negative regulation of secretion of lysosomal enzymes]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000188 [regulation of cholesterol homeostasis]
GO:2000189 [positive regulation of cholesterol homeostasis]
Show all
 387 aa
43.6 kDa 		No 0
NR1H3-003
ENSP00000385073
ENST00000405576
B5MBY7 [Direct mapping]
Oxysterols receptor LXR-alpha
Show all
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 342 aa
38.9 kDa 		No 0
NR1H3-006
ENSP00000384745
ENST00000405853
Q13133 [Direct mapping]
Oxysterols receptor LXR-alpha
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0010870 [positive regulation of receptor biosynthetic process]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032369 [negative regulation of lipid transport]
GO:0032376 [positive regulation of cholesterol transport]
GO:0032570 [response to progesterone]
GO:0032810 [sterol response element binding]
GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway]
GO:0042632 [cholesterol homeostasis]
GO:0042752 [regulation of circadian rhythm]
GO:0043031 [negative regulation of macrophage activation]
GO:0043235 [receptor complex]
GO:0043277 [apoptotic cell clearance]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048550 [negative regulation of pinocytosis]
GO:0050728 [negative regulation of inflammatory response]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0055088 [lipid homeostasis]
GO:0055092 [sterol homeostasis]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0070328 [triglyceride homeostasis]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0090188 [negative regulation of pancreatic juice secretion]
GO:0090341 [negative regulation of secretion of lysosomal enzymes]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000188 [regulation of cholesterol homeostasis]
GO:2000189 [positive regulation of cholesterol homeostasis]
Show all
 387 aa
43.6 kDa 		No 0
NR1H3-007
ENSP00000403798
ENST00000436778
C9JJ16 [Direct mapping]
Oxysterols receptor LXR-alpha
Show all
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 202 aa
22 kDa 		No 0
NR1H3-010
ENSP00000391005
ENST00000444396
C9J4R0 [Direct mapping]
Oxysterols receptor LXR-alpha
Show all
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 194 aa
21.2 kDa 		No 0
NR1H3-011
ENSP00000413095
ENST00000457932
C9JTS4 [Direct mapping]
Oxysterols receptor LXR-alpha
Show all
Predicted intracellular proteins
Show all
 77 aa
7.8 kDa 		No 0
NR1H3-012
ENSP00000412636
ENST00000412937
C9J2C8 [Direct mapping]
Oxysterols receptor LXR-alpha
Show all
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043565 [sequence-specific DNA binding]
Show all
 134 aa
14.8 kDa 		No 0
NR1H3-013
ENSP00000415591
ENST00000449369
C9JCS0 [Direct mapping]
Oxysterols receptor LXR-alpha
Show all
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 205 aa
22.4 kDa 		No 0
NR1H3-016
ENSP00000403696
ENST00000436029
C9JBS2 [Direct mapping]
Oxysterols receptor LXR-alpha
Show all
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 212 aa
23.1 kDa 		No 0
NR1H3-017
ENSP00000396132
ENST00000437276
C9JEC2 [Direct mapping]
Oxysterols receptor LXR-alpha
Show all
Predicted intracellular proteins
Show all
 68 aa
6.9 kDa 		No 0
NR1H3-023
ENSP00000433271
ENST00000481889
E9PLL4 [Direct mapping]
Oxysterols receptor LXR-alpha
Show all
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 466 aa
52.8 kDa 		No 0
NR1H3-030
ENSP00000387946
ENST00000441012
Q13133 [Direct mapping]
Oxysterols receptor LXR-alpha
F1D8N1 [Target identity:100%; Query identity:100%]
Liver X nuclear receptor alpha variant 1
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0010870 [positive regulation of receptor biosynthetic process]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032369 [negative regulation of lipid transport]
GO:0032376 [positive regulation of cholesterol transport]
GO:0032570 [response to progesterone]
GO:0032810 [sterol response element binding]
GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway]
GO:0042632 [cholesterol homeostasis]
GO:0042752 [regulation of circadian rhythm]
GO:0043031 [negative regulation of macrophage activation]
GO:0043235 [receptor complex]
GO:0043277 [apoptotic cell clearance]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048550 [negative regulation of pinocytosis]
GO:0050728 [negative regulation of inflammatory response]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0055088 [lipid homeostasis]
GO:0055092 [sterol homeostasis]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0070328 [triglyceride homeostasis]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0090188 [negative regulation of pancreatic juice secretion]
GO:0090341 [negative regulation of secretion of lysosomal enzymes]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000188 [regulation of cholesterol homeostasis]
GO:2000189 [positive regulation of cholesterol homeostasis]
Show all
 447 aa
50.4 kDa 		No 0
NR1H3-031
ENSP00000378793
ENST00000395397
Q13133 [Direct mapping]
Oxysterols receptor LXR-alpha
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0010870 [positive regulation of receptor biosynthetic process]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032369 [negative regulation of lipid transport]
GO:0032376 [positive regulation of cholesterol transport]
GO:0032570 [response to progesterone]
GO:0032810 [sterol response element binding]
GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway]
GO:0042632 [cholesterol homeostasis]
GO:0042752 [regulation of circadian rhythm]
GO:0043031 [negative regulation of macrophage activation]
GO:0043235 [receptor complex]
GO:0043277 [apoptotic cell clearance]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048550 [negative regulation of pinocytosis]
GO:0050728 [negative regulation of inflammatory response]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0055088 [lipid homeostasis]
GO:0055092 [sterol homeostasis]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0070328 [triglyceride homeostasis]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0090188 [negative regulation of pancreatic juice secretion]
GO:0090341 [negative regulation of secretion of lysosomal enzymes]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000188 [regulation of cholesterol homeostasis]
GO:2000189 [positive regulation of cholesterol homeostasis]
Show all
 402 aa
45.7 kDa 		No 0
NR1H3-032
ENSP00000432073
ENST00000527949
E9PID2 [Direct mapping]
Oxysterols receptor LXR-alpha
Show all
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 296 aa
34.1 kDa 		No 0
NR1H3-037
ENSP00000434650
ENST00000531660
E9PPA1 [Direct mapping]
Oxysterols receptor LXR-alpha
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043401 [steroid hormone mediated signaling pathway]
Show all
 167 aa
18.6 kDa 		No 0
NR1H3-201
ENSP00000477707
ENST00000616973
B4DXU5 [Direct mapping]
Oxysterols receptor LXR-alpha; cDNA FLJ56172, highly similar to Oxysterols receptor LXR-alpha
Show all
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0008270 [zinc ion binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0042632 [cholesterol homeostasis]
GO:0043031 [negative regulation of macrophage activation]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044255 [cellular lipid metabolic process]
GO:0045861 [negative regulation of proteolysis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046965 [retinoid X receptor binding]
GO:0046982 [protein heterodimerization activity]
GO:0050728 [negative regulation of inflammatory response]
GO:0055088 [lipid homeostasis]
GO:0055092 [sterol homeostasis]
GO:0070328 [triglyceride homeostasis]
GO:0090188 [negative regulation of pancreatic juice secretion]
GO:0090341 [negative regulation of secretion of lysosomal enzymes]
GO:2000188 [regulation of cholesterol homeostasis]
Show all
 453 aa
51.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.