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CD44

GENERAL INFORMATION

Gene name

 CD44

Gene description

 CD44 molecule (Indian blood group)

Protein class

 Blood group antigen proteins
Cancer-related genes
CD markers
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 25
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in most epithelial and lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. External characterization data supports antibody staining. Pending retesting.

Reliability score

 Supported based on 3 antibodies.
HPA005785 , CAB000112 , CAB000316
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA005785
CAB000112
CAB000316

GENE INFORMATION

Gene name

 CD44 (HGNC Symbol)

Synonyms

 CD44R, CSPG8, HCELL, IN, MC56, MDU2, MDU3, MIC4, Pgp1

Description

 CD44 molecule (Indian blood group) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p13

Chromosome location (bp)

 35138870 - 35232402

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000026508 (version 83.38)

Entrez gene

 960

UniProt

 P16070 (UniProt - Evidence at protein level)

neXtProt

 NX_P16070

Antibodypedia

 CD44 antibodies

PROTEIN BROWSER
«
CD44-001
CD44-002
CD44-003
CD44-004
CD44-005
CD44-006
CD44-007
CD44-008
CD44-011
CD44-015
CD44-019
CD44-024
CD44-026
CD44-028
CD44-030
CD44-032
CD44-033
CD44-034
CD44-035
CD44-036
CD44-037
CD44-038
CD44-039
CD44-040
CD44-041
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD44-001
ENSP00000398632
ENST00000428726
P16070 [Direct mapping]
CD44 antigen
Show all
CD markers
Blood group antigen proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0002246 [wound healing involved in inflammatory response]
GO:0004415 [hyalurononglucosaminidase activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0035692 [macrophage migration inhibitory factor receptor complex]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050900 [leukocyte migration]
GO:0051216 [cartilage development]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070487 [monocyte aggregation]
GO:1900625 [positive regulation of monocyte aggregation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
Show all
 742 aa
81.5 kDa 		Yes 1
CD44-002
ENSP00000278386
ENST00000278386
P16070 [Direct mapping]
CD44 antigen
Show all
CD markers
Blood group antigen proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004415 [hyalurononglucosaminidase activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0016337 [single organismal cell-cell adhesion]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0035692 [macrophage migration inhibitory factor receptor complex]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050900 [leukocyte migration]
GO:0051216 [cartilage development]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070487 [monocyte aggregation]
GO:1900625 [positive regulation of monocyte aggregation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
Show all
 139 aa
15.6 kDa 		Yes 0
CD44-003
ENSP00000263398
ENST00000263398
P16070 [Direct mapping]
CD44 antigen
Show all
CD markers
Blood group antigen proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004415 [hyalurononglucosaminidase activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0016337 [single organismal cell-cell adhesion]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0035692 [macrophage migration inhibitory factor receptor complex]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050900 [leukocyte migration]
GO:0051216 [cartilage development]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070487 [monocyte aggregation]
GO:1900625 [positive regulation of monocyte aggregation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
Show all
 361 aa
39.4 kDa 		Yes 1
CD44-004
ENSP00000389830
ENST00000415148
P16070 [Direct mapping]
CD44 antigen
Show all
CD markers
Blood group antigen proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004415 [hyalurononglucosaminidase activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0016337 [single organismal cell-cell adhesion]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0035692 [macrophage migration inhibitory factor receptor complex]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050900 [leukocyte migration]
GO:0051216 [cartilage development]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070487 [monocyte aggregation]
GO:1900625 [positive regulation of monocyte aggregation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
Show all
 699 aa
76.6 kDa 		Yes 1
CD44-005
ENSP00000392331
ENST00000433892
P16070 [Direct mapping]
CD44 antigen
Show all
CD markers
Blood group antigen proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004415 [hyalurononglucosaminidase activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0016337 [single organismal cell-cell adhesion]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0035692 [macrophage migration inhibitory factor receptor complex]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050900 [leukocyte migration]
GO:0051216 [cartilage development]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070487 [monocyte aggregation]
GO:1900625 [positive regulation of monocyte aggregation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
Show all
 493 aa
53.4 kDa 		Yes 1
CD44-006
ENSP00000398099
ENST00000442151
H0Y5E4 [Direct mapping]
CD44 antigen
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005540 [hyaluronic acid binding]
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
Show all
 294 aa
31.9 kDa 		Yes 1
CD44-007
ENSP00000309732
ENST00000352818
P16070 [Direct mapping]
CD44 antigen
Show all
CD markers
Blood group antigen proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004415 [hyalurononglucosaminidase activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0016337 [single organismal cell-cell adhesion]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0035692 [macrophage migration inhibitory factor receptor complex]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050900 [leukocyte migration]
GO:0051216 [cartilage development]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070487 [monocyte aggregation]
GO:1900625 [positive regulation of monocyte aggregation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
Show all
 340 aa
37.3 kDa 		Yes 1
CD44-008
ENSP00000404447
ENST00000434472
P16070 [Direct mapping]
CD44 antigen
Show all
CD markers
Blood group antigen proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004415 [hyalurononglucosaminidase activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0016337 [single organismal cell-cell adhesion]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0035692 [macrophage migration inhibitory factor receptor complex]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050900 [leukocyte migration]
GO:0051216 [cartilage development]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070487 [monocyte aggregation]
GO:1900625 [positive regulation of monocyte aggregation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
Show all
 429 aa
46.6 kDa 		Yes 1
CD44-011
ENSP00000435377
ENST00000526025
E9PKC6 [Direct mapping]
CD44 antigen
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005540 [hyaluronic acid binding]
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
Show all
 78 aa
8.8 kDa 		Yes 0
CD44-015
ENSP00000434920
ENST00000525469
H0YE40 [Direct mapping]
CD44 antigen
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
Show all
 82 aa
9.1 kDa 		No 0
CD44-019
ENSP00000432704
ENST00000526669
H0YD13 [Direct mapping]
CD44 antigen
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005540 [hyaluronic acid binding]
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
Show all
 206 aa
22.7 kDa 		Yes 1
CD44-024
ENSP00000279452
ENST00000279452
H0Y2P0 [Direct mapping]
CD44 antigen
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005540 [hyaluronic acid binding]
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
Show all
 287 aa
31 kDa 		No 1
CD44-026
ENSP00000436451
ENST00000524922
H0YES0 [Direct mapping]
CD44 antigen
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 118 aa
13.5 kDa 		No 0
CD44-028
ENSP00000436623
ENST00000525685
H0YEV3 [Direct mapping]
CD44 antigen
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
Show all
 243 aa
26.7 kDa 		No 0
CD44-030
ENSP00000433189
ENST00000531873
H0YD90 [Direct mapping]
CD44 antigen
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005540 [hyaluronic acid binding]
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
GO:0033674 [positive regulation of kinase activity]
Show all
 195 aa
21.2 kDa 		No 0
CD44-032
ENSP00000278385
ENST00000278385
J3KN83 [Direct mapping]
CD44 antigen
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
Show all
 232 aa
24.7 kDa 		No 1
CD44-033
ENSP00000432405
ENST00000525211
H0YCV9 [Direct mapping]
CD44 antigen
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005540 [hyaluronic acid binding]
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
Show all
 249 aa
27.3 kDa 		No 0
CD44-034
ENSP00000435321
ENST00000533222
H0YEA1 [Direct mapping]
CD44 antigen
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 193 aa
21 kDa 		No 0
CD44-035
ENSP00000432718
ENST00000528455
H0YD17 [Direct mapping]
CD44 antigen
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005540 [hyaluronic acid binding]
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
Show all
 230 aa
25.7 kDa 		No 0
CD44-036
ENSP00000436980
ENST00000525688
H0YF08 [Direct mapping]
CD44 antigen
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
Show all
 187 aa
20.1 kDa 		No 1
CD44-037
ENSP00000431860
ENST00000528672
H0YCL4 [Direct mapping]
CD44 antigen
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 195 aa
21.5 kDa 		No 0
CD44-038
ENSP00000434530
ENST00000527889
H0YDX6 [Direct mapping]
CD44 antigen
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005540 [hyaluronic acid binding]
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
Show all
 181 aa
19.5 kDa 		No 0
CD44-039
ENSP00000436549
ENST00000531110
H0YEU1 [Direct mapping]
CD44 antigen
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 249 aa
27.3 kDa 		No 0
CD44-040
ENSP00000434465
ENST00000526000
H0YDW7 [Direct mapping]
CD44 antigen
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005540 [hyaluronic acid binding]
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
Show all
 240 aa
26 kDa 		No 0
CD44-041
ENSP00000434418
ENST00000526553
H0YDV8 [Direct mapping]
CD44 antigen
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 191 aa
21.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.