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KCNG1

GENERAL INFORMATION

Gene name

 KCNG1

Gene description

 Potassium channel, voltage gated modifier subfamily G, member 1

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (urothelial cancer)
HPA (cell line):Cell line enhanced (hTCEpi, U-138 MG, WM-115)
HPA (normal tissue):Tissue enhanced (endometrium, seminal vesicle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded. External characterization data supports antibody staining.

Reliability score

 Approved based on 2 antibodies.
HPA039530 , HPA040024
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Endometrial cancer

STAINING SUMMARY
HPA039530
HPA040024

GENE INFORMATION

Gene name

 KCNG1 (HGNC Symbol)

Synonyms

 K13, KCNG, kH2, Kv6.1

Description

 Potassium channel, voltage gated modifier subfamily G, member 1 (HGNC Symbol)

Entrez gene summary

 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.13

Chromosome location (bp)

 51003656 - 51023129

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000026559 (version 83.38)

Entrez gene

 3755

UniProt

 Q9UIX4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UIX4

Antibodypedia

 KCNG1 antibodies

PROTEIN BROWSER
KCNG1-001
KCNG1-002
KCNG1-003
KCNG1-004
KCNG1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNG1-001
ENSP00000394093
ENST00000424171
A2A2I8 [Direct mapping]
Potassium voltage-gated channel subfamily G member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051260 [protein homooligomerization]
GO:0071805 [potassium ion transmembrane transport]
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 180 aa
20.9 kDa 		No 0
KCNG1-002
ENSP00000360626
ENST00000371571
Q9UIX4 [Direct mapping]
Potassium voltage-gated channel subfamily G member 1
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Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0005216 [ion channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005267 [potassium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
GO:1902259 [regulation of delayed rectifier potassium channel activity]
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 513 aa
57.9 kDa 		No 7
KCNG1-003
ENSP00000408116
ENST00000433903
Q5JXL4 [Direct mapping]
Potassium voltage-gated channel subfamily G member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005251 [delayed rectifier potassium channel activity]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051260 [protein homooligomerization]
GO:0071805 [potassium ion transmembrane transport]
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 96 aa
11 kDa 		No 0
KCNG1-004
ENSP00000394075
ENST00000439216
A0A075B6P6 [Direct mapping]
Potassium voltage-gated channel subfamily G member 1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0051260 [protein homooligomerization]
GO:0071805 [potassium ion transmembrane transport]
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 258 aa
29.5 kDa 		No 1
KCNG1-005
ENSP00000396058
ENST00000447736
A2A2I9 [Direct mapping]
Potassium voltage-gated channel subfamily G member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005251 [delayed rectifier potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0071805 [potassium ion transmembrane transport]
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 48 aa
5.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.