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Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004697 [protein kinase C activity] GO:0004699 [calcium-independent protein kinase C activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0016020 [membrane] GO:0017160 [Ral GTPase binding] GO:0019899 [enzyme binding] GO:0030168 [platelet activation] GO:0034351 [negative regulation of glial cell apoptotic process] GO:0035556 [intracellular signal transduction] GO:0045618 [positive regulation of keratinocyte differentiation] GO:0046872 [metal ion binding] GO:0050861 [positive regulation of B cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0060252 [positive regulation of glial cell proliferation] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:2000810 [regulation of bicellular tight junction assembly]
