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SH2D2A

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GENERAL INFORMATION

Gene name

 SH2D2A

Gene description

 SH2 domain containing 2A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (Karpas-707, HDLM-2, HMC-1)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707, HDLM-2, HMC-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SH2D2A (HGNC Symbol)

Synonyms

 F2771, TSAd

Description

 SH2 domain containing 2A (HGNC Symbol)

Entrez gene summary

 This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Chromosome

 1

Cytoband

 q23.1

Chromosome location (bp)

 156806243 - 156816862

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000027869 (version 83.38)

Entrez gene

 9047

UniProt

 Q9NP31 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NP31

Antibodypedia

 SH2D2A antibodies

PROTEIN BROWSER
SH2D2A-001
SH2D2A-002
SH2D2A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SH2D2A-001
ENSP00000357182
ENST00000368199
Q9NP31 [Direct mapping]
SH2 domain-containing protein 2A
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0009967 [positive regulation of signal transduction]
GO:0017124 [SH3 domain binding]
GO:0030154 [cell differentiation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
Show all
 389 aa
42.9 kDa 		No 0
SH2D2A-002
ENSP00000357181
ENST00000368198
Q9NP31 [Direct mapping]
SH2 domain-containing protein 2A
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0009967 [positive regulation of signal transduction]
GO:0017124 [SH3 domain binding]
GO:0030154 [cell differentiation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
Show all
 371 aa
41 kDa 		No 0
SH2D2A-201
ENSP00000376123
ENST00000392306
Q9NP31 [Direct mapping]
SH2 domain-containing protein 2A
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0008283 [cell proliferation]
GO:0009967 [positive regulation of signal transduction]
GO:0017124 [SH3 domain binding]
GO:0030154 [cell differentiation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
Show all
 399 aa
44.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.