Tissue expression of SH2D2A - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SH2D2A
Gene description	SH2 domain containing 2A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (appendix)
GTEx:	Tissue enhanced (spleen)
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (appendix)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	SH2D2A (HGNC Symbol)
Synonyms	F2771, TSAd
Description	SH2 domain containing 2A (HGNC Symbol)
Entrez gene summary	This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Chromosome	1
Cytoband	q23.1
Chromosome location (bp)	156806243 - 156816862
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000027869 (version 83.38)
Entrez gene	9047
UniProt	Q9NP31 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NP31
Antibodypedia	SH2D2A antibodies

PROTEIN BROWSER

SH2D2A-001	SH2D2A-002	SH2D2A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SH2D2A-001 ENSP00000357182 ENST00000368199	Q9NP31 [Direct mapping] SH2 domain-containing protein 2A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0009967 [positive regulation of signal transduction] GO:0017124 [SH3 domain binding] GO:0030154 [cell differentiation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] Show all	389 aa 42.9 kDa	No	0
SH2D2A-002 ENSP00000357181 ENST00000368198	Q9NP31 [Direct mapping] SH2 domain-containing protein 2A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0009967 [positive regulation of signal transduction] GO:0017124 [SH3 domain binding] GO:0030154 [cell differentiation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] Show all	371 aa 41 kDa	No	0
SH2D2A-201 ENSP00000376123 ENST00000392306	Q9NP31 [Direct mapping] SH2 domain-containing protein 2A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0008283 [cell proliferation] GO:0009967 [positive regulation of signal transduction] GO:0017124 [SH3 domain binding] GO:0030154 [cell differentiation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] Show all	399 aa 44.1 kDa	No	0