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BCLAF1

GENERAL INFORMATION

Gene name

 BCLAF1

Gene description

 BCL2-associated transcription factor 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA006669 , HPA027770
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable) and colorectal cancer (favourable).
Breast cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006669
HPA027770

GENE INFORMATION

Gene name

 BCLAF1 (HGNC Symbol)

Synonyms

 BTF, KIAA0164

Description

 BCL2-associated transcription factor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q23.3

Chromosome location (bp)

 136256863 - 136289851

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000029363 (version 83.38)

Entrez gene

 9774

UniProt

 Q9NYF8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NYF8

Antibodypedia

 BCLAF1 antibodies

PROTEIN BROWSER
BCLAF1-001
BCLAF1-003
BCLAF1-005
BCLAF1-006
BCLAF1-010
BCLAF1-011
BCLAF1-020
BCLAF1-201
BCLAF1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BCLAF1-001
ENSP00000431734
ENST00000529826
E9PK09 [Direct mapping]
Bcl-2-associated transcription factor 1
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006915 [apoptotic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:2001022 [positive regulation of response to DNA damage stimulus]
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 726 aa
83.2 kDa 		No 0
BCLAF1-003
ENSP00000435210
ENST00000531224
Q9NYF8 [Direct mapping]
Bcl-2-associated transcription factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0016607 [nuclear speck]
GO:0043065 [positive regulation of apoptotic process]
GO:0043620 [regulation of DNA-templated transcription in response to stress]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:2000144 [positive regulation of DNA-templated transcription, initiation]
GO:2001022 [positive regulation of response to DNA damage stimulus]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
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 920 aa
106.1 kDa 		No 0
BCLAF1-005
ENSP00000435441
ENST00000527536
E9PK91 [Direct mapping]
Bcl-2-associated transcription factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006915 [apoptotic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:2001022 [positive regulation of response to DNA damage stimulus]
Show all
 871 aa
100.4 kDa 		No 0
BCLAF1-006
ENSP00000434826
ENST00000527759
Q9NYF8 [Direct mapping]
Bcl-2-associated transcription factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0016607 [nuclear speck]
GO:0043065 [positive regulation of apoptotic process]
GO:0043620 [regulation of DNA-templated transcription in response to stress]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:2000144 [positive regulation of DNA-templated transcription, initiation]
GO:2001022 [positive regulation of response to DNA damage stimulus]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 918 aa
105.9 kDa 		No 0
BCLAF1-010
ENSP00000436501
ENST00000530767
Q9NYF8 [Direct mapping]
Bcl-2-associated transcription factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0016607 [nuclear speck]
GO:0043065 [positive regulation of apoptotic process]
GO:0043620 [regulation of DNA-templated transcription in response to stress]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:2000144 [positive regulation of DNA-templated transcription, initiation]
GO:2001022 [positive regulation of response to DNA damage stimulus]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 747 aa
85.9 kDa 		No 0
BCLAF1-011
ENSP00000376159
ENST00000392348
Q9NYF8 [Direct mapping]
Bcl-2-associated transcription factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0016607 [nuclear speck]
GO:0043065 [positive regulation of apoptotic process]
GO:0043620 [regulation of DNA-templated transcription in response to stress]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:2000144 [positive regulation of DNA-templated transcription, initiation]
GO:2001022 [positive regulation of response to DNA damage stimulus]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 869 aa
100.2 kDa 		No 0
BCLAF1-020
ENSP00000437018
ENST00000534762
H0YF14 [Direct mapping]
Bcl-2-associated transcription factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006915 [apoptotic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:2001022 [positive regulation of response to DNA damage stimulus]
Show all
 187 aa
22 kDa 		No 0
BCLAF1-201
ENSP00000229446
ENST00000353331
Q9NYF8 [Direct mapping]
Bcl-2-associated transcription factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0016607 [nuclear speck]
GO:0043065 [positive regulation of apoptotic process]
GO:0043620 [regulation of DNA-templated transcription in response to stress]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:2000144 [positive regulation of DNA-templated transcription, initiation]
GO:2001022 [positive regulation of response to DNA damage stimulus]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 869 aa
100.2 kDa 		No 0
BCLAF1-202
ENSP00000487249
ENST00000628517
E9PKI6 [Direct mapping]
Bcl-2-associated transcription factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006915 [apoptotic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:2001022 [positive regulation of response to DNA damage stimulus]
Show all
 752 aa
86.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.