Cell atlas - HMGB3 - The Human Protein Atlas

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HMGB3

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	HMGB3
Gene description	High mobility group box 3
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA062583
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & nucleoli.

Main location

Nucleus (approved), Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA062583	A-431	Nucleus
			Nucleoli
			Intermediate filaments
	HPA062583	MCF7	Nucleus
	HPA062583	MCF7	Nucleoli
	HPA062583	U-2 OS	Nucleus
	HPA062583	U-2 OS	Nucleoli

GENE INFORMATION
Gene name	HMGB3 (HGNC Symbol)
Synonyms	HMG2A, HMG4, MGC90319
Description	High mobility group box 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	150980509 - 150990775
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000029993 (version 83.38)
Entrez gene	3149
UniProt	O15347 (UniProt - Evidence at protein level)
neXtProt	NX_O15347
Antibodypedia	HMGB3 antibodies

PROTEIN BROWSER

HMGB3-001	HMGB3-002	HMGB3-003	HMGB3-004	HMGB3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HMGB3-001 ENSP00000359393 ENST00000325307	O15347 [Direct mapping] High mobility group protein B3 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000400 [four-way junction DNA binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005694 [chromosome] GO:0006310 [DNA recombination] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0008301 [DNA binding, bending] GO:0032392 [DNA geometric change] GO:0044822 [poly(A) RNA binding] Show all	200 aa 23 kDa	No	0
HMGB3-002 ENSP00000410354 ENST00000419110	E7ES08 [Direct mapping] High mobility group protein B3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005634 [nucleus] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0045596 [negative regulation of cell differentiation] Show all	188 aa 21.4 kDa	No	0
HMGB3-003 ENSP00000405601 ENST00000455596	E7EQU1 [Direct mapping] High mobility group protein B3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005634 [nucleus] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0045596 [negative regulation of cell differentiation] Show all	193 aa 22.1 kDa	No	0
HMGB3-004 ENSP00000417027 ENST00000430118	E9PES6 [Direct mapping] High mobility group protein B3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005634 [nucleus] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0045596 [negative regulation of cell differentiation] Show all	153 aa 17.5 kDa	No	0
HMGB3-201 ENSP00000442758 ENST00000448905	O15347 [Direct mapping] High mobility group protein B3 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000400 [four-way junction DNA binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005694 [chromosome] GO:0006310 [DNA recombination] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0008301 [DNA binding, bending] GO:0032392 [DNA geometric change] GO:0044822 [poly(A) RNA binding] Show all	200 aa 23 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.