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HMGB3

GENERAL INFORMATION

Gene name

 HMGB3

Gene description

 High mobility group box 3

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in selected tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Supported based on 1 antibody.
HPA062583
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable) and renal cancer (favourable).
Ovarian cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA062583

GENE INFORMATION

Gene name

 HMGB3 (HGNC Symbol)

Synonyms

 HMG2A, HMG4, MGC90319

Description

 High mobility group box 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 150980509 - 150990775

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000029993 (version 83.38)

Entrez gene

 3149

UniProt

 O15347 (UniProt - Evidence at protein level)

neXtProt

 NX_O15347

Antibodypedia

 HMGB3 antibodies

PROTEIN BROWSER
HMGB3-001
HMGB3-002
HMGB3-003
HMGB3-004
HMGB3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HMGB3-001
ENSP00000359393
ENST00000325307
O15347 [Direct mapping]
High mobility group protein B3
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000400 [four-way junction DNA binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0006310 [DNA recombination]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0008301 [DNA binding, bending]
GO:0032392 [DNA geometric change]
GO:0044822 [poly(A) RNA binding]
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 200 aa
23 kDa 		No 0
HMGB3-002
ENSP00000410354
ENST00000419110
E7ES08 [Direct mapping]
High mobility group protein B3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0045596 [negative regulation of cell differentiation]
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 188 aa
21.4 kDa 		No 0
HMGB3-003
ENSP00000405601
ENST00000455596
E7EQU1 [Direct mapping]
High mobility group protein B3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0045596 [negative regulation of cell differentiation]
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 193 aa
22.1 kDa 		No 0
HMGB3-004
ENSP00000417027
ENST00000430118
E9PES6 [Direct mapping]
High mobility group protein B3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0045596 [negative regulation of cell differentiation]
Show all
 153 aa
17.5 kDa 		No 0
HMGB3-201
ENSP00000442758
ENST00000448905
O15347 [Direct mapping]
High mobility group protein B3
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000400 [four-way junction DNA binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0006310 [DNA recombination]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0008301 [DNA binding, bending]
GO:0032392 [DNA geometric change]
GO:0044822 [poly(A) RNA binding]
Show all
 200 aa
23 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.