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GAB2

GENERAL INFORMATION

Gene name

 GAB2

Gene description

 GRB2-associated binding protein 2

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (SH-SY5Y)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA000271 , CAB022159
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA000271
CAB022159

GENE INFORMATION

Gene name

 GAB2 (HGNC Symbol)

Synonyms

 KIAA0571

Description

 GRB2-associated binding protein 2 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

Chromosome

 11

Cytoband

 q14.1

Chromosome location (bp)

 78215297 - 78418348

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000033327 (version 83.38)

Entrez gene

 9846

UniProt

 Q9UQC2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UQC2

Antibodypedia

 GAB2 antibodies

PROTEIN BROWSER
GAB2-001
GAB2-002
GAB2-003
GAB2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GAB2-001
ENSP00000354952
ENST00000361507
Q9UQC2 [Direct mapping]
GRB2-associated-binding protein 2
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0016477 [cell migration]
GO:0030316 [osteoclast differentiation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0045087 [innate immune response]
GO:0048015 [phosphatidylinositol-mediated signaling]
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 676 aa
74.5 kDa 		No 0
GAB2-002
ENSP00000343959
ENST00000340149
Q9UQC2 [Direct mapping]
GRB2-associated-binding protein 2
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0030316 [osteoclast differentiation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0045087 [innate immune response]
GO:0048015 [phosphatidylinositol-mediated signaling]
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 638 aa
70 kDa 		No 0
GAB2-003
ENSP00000433762
ENST00000528886
E9PJE2 [Direct mapping]
GRB2-associated-binding protein 2
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
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 131 aa
14.7 kDa 		No 0
GAB2-005
ENSP00000431868
ENST00000530915
E9PJ26 [Direct mapping]
GRB2-associated-binding protein 2
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
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 102 aa
11.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.