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VCL

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GENERAL INFORMATION

Gene name

 VCL

Gene description

 Vinculin

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the focal adhesion sites.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Focal adhesion sites (validated)

GFP

 The location(s) are Validated based on analysis of GFP-tagged protein.

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA063777
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ASSAYS
RNA expression
Human cells
GFP

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the focal adhesion sites.

Main location

 Focal adhesion sites (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA063777 RT4 Focal adhesion sites
HPA063777 U-2 OS Focal adhesion sites

GFP

Antibody

 HPA063777

Validation

N-terminal tag
BAC cell line: 6401
Validated: Antibody staining overlaps with GFP tagged protein

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

BAC id

Tag

Location antibody staining

Location tagged protein
HPA063777 HeLa 6401 N-terminal Focal adhesion sites Focal adhesion sites
HPA063777 HeLa Normal - Focal adhesion sites -

GENE INFORMATION

Gene name

 VCL

Synonyms

Description

 Vinculin (HGNC Symbol)

Entrez gene summary

 Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q22.2

Chromosome location (bp)

 73995193 - 74121363

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000035403 (version 83.38)

Entrez gene

 7414

UniProt

 P18206 (UniProt - Evidence at protein level)

neXtProt

 NX_P18206

Antibodypedia

 VCL antibodies

PROTEIN BROWSER
VCL-001
VCL-002
VCL-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VCL-001
ENSP00000361841
ENST00000372755
P18206 [Direct mapping]
Vinculin
A0A024QZN4 [Target identity:100%; Query identity:100%]
Vinculin, isoform CRA_c
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium]
GO:0002162 [dystroglycan binding]
GO:0002576 [platelet degranulation]
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005623 [cell]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0006936 [muscle contraction]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0008013 [beta-catenin binding]
GO:0015629 [actin cytoskeleton]
GO:0030032 [lamellipodium assembly]
GO:0030055 [cell-substrate junction]
GO:0030168 [platelet activation]
GO:0030336 [negative regulation of cell migration]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0043034 [costamere]
GO:0043234 [protein complex]
GO:0043297 [apical junction assembly]
GO:0045121 [membrane raft]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0090136 [epithelial cell-cell adhesion]
GO:0090636 [outer dense plaque of desmosome]
GO:0090637 [inner dense plaque of desmosome]
GO:1903561 [extracellular vesicle]
GO:1990357 [terminal web]
Show all
 1066 aa
116.7 kDa 		No 0
VCL-002
ENSP00000415489
ENST00000436396
Q5JQ13 [Direct mapping]
Vinculin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0007155 [cell adhesion]
GO:0015629 [actin cytoskeleton]
GO:0051015 [actin filament binding]
Show all
 806 aa
87.4 kDa 		No 0
VCL-201
ENSP00000211998
ENST00000211998
P18206 [Direct mapping]
Vinculin
V9HWK2 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 114; Vinculin, isoform CRA_b
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002009 [morphogenesis of an epithelium]
GO:0002162 [dystroglycan binding]
GO:0002576 [platelet degranulation]
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005623 [cell]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005916 [fascia adherens]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0006936 [muscle contraction]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0008013 [beta-catenin binding]
GO:0015629 [actin cytoskeleton]
GO:0030032 [lamellipodium assembly]
GO:0030055 [cell-substrate junction]
GO:0030168 [platelet activation]
GO:0030334 [regulation of cell migration]
GO:0030336 [negative regulation of cell migration]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0043034 [costamere]
GO:0043234 [protein complex]
GO:0043297 [apical junction assembly]
GO:0045121 [membrane raft]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0048675 [axon extension]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0090136 [epithelial cell-cell adhesion]
GO:0090636 [outer dense plaque of desmosome]
GO:0090637 [inner dense plaque of desmosome]
GO:1903561 [extracellular vesicle]
GO:1990357 [terminal web]
Show all
 1134 aa
123.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.