Cell atlas - MYOM2 - The Human Protein Atlas

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MYOM2

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	MYOM2
Gene description	Myomesin 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Group enriched (HEK 293, SCLC-21H, U-266/84)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA001765
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HEK 293, SCLC-21H, U-266/84) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001765	HEK 293	Mitochondria

GENE INFORMATION
Gene name	MYOM2
Synonyms
Description	Myomesin 2 (HGNC Symbol)
Entrez gene summary	The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD and 165 kD. The predicted MYOM2 protein contains 1,465 amino acids. Like MYOM1, MYOM2 has a unique N-terminal domain followed by 12 repeat domains with strong homology to either fibronectin type III or immunoglobulin C2 domains. Protein sequence comparisons suggested that the MYOM2 protein and bovine M protein are identical. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p23.3
Chromosome location (bp)	2045040 - 2165552
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000036448 (version 83.38)
Entrez gene	9172
UniProt	P54296 (UniProt - Evidence at protein level)
neXtProt	NX_P54296
Antibodypedia	MYOM2 antibodies

PROTEIN BROWSER

MYOM2-001	MYOM2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYOM2-001 ENSP00000262113 ENST00000262113	P54296 [Direct mapping] Myomesin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0006936 [muscle contraction] GO:0008307 [structural constituent of muscle] GO:0031430 [M band] GO:0032982 [myosin filament] Show all	1465 aa 164.9 kDa	No	0
MYOM2-002 ENSP00000428396 ENST00000523438	E7EWH9 [Direct mapping] Myomesin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	890 aa 99.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.