Expression of MYOM2 in cancer - Summary - The Human Protein Atlas

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MYOM2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MYOM2
Gene description	Myomesin 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (HEK93, SCLC-21H, U-266/84)
HPA (normal tissue):	Group enriched (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression, high in myocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA001765 , HPA005953
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001765	HPA005953

GENE INFORMATION
Gene name	MYOM2
Synonyms
Description	Myomesin 2 (HGNC Symbol)
Entrez gene summary	The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD and 165 kD. The predicted MYOM2 protein contains 1,465 amino acids. Like MYOM1, MYOM2 has a unique N-terminal domain followed by 12 repeat domains with strong homology to either fibronectin type III or immunoglobulin C2 domains. Protein sequence comparisons suggested that the MYOM2 protein and bovine M protein are identical. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p23.3
Chromosome location (bp)	2045040 - 2165552
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000036448 (version 83.38)
Entrez gene	9172
UniProt	P54296 (UniProt - Evidence at protein level)
neXtProt	NX_P54296
Antibodypedia	MYOM2 antibodies

PROTEIN BROWSER

MYOM2-001	MYOM2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYOM2-001 ENSP00000262113 ENST00000262113	P54296 [Direct mapping] Myomesin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0006936 [muscle contraction] GO:0008307 [structural constituent of muscle] GO:0031430 [M band] GO:0032982 [myosin filament] Show all	1465 aa 164.9 kDa	No	0
MYOM2-002 ENSP00000428396 ENST00000523438	E7EWH9 [Direct mapping] Myomesin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	890 aa 99.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.