Cell atlas - CYP46A1 - The Human Protein Atlas

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CYP46A1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CYP46A1
Gene description	Cytochrome P450, family 46, subfamily A, polypeptide 1
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (U-937, AF22)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (U-937, AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CYP46A1 (HGNC Symbol)
Synonyms	CYP46
Description	Cytochrome P450, family 46, subfamily A, polypeptide 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q32.2
Chromosome location (bp)	99684304 - 99727301
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000036530 (version 83.38)
Entrez gene	10858
UniProt	Q9Y6A2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6A2
Antibodypedia	CYP46A1 antibodies

PROTEIN BROWSER

CYP46A1-001	CYP46A1-003	CYP46A1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYP46A1-001 ENSP00000261835 ENST00000261835	Q9Y6A2 [Direct mapping] Cholesterol 24-hydroxylase Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006699 [bile acid biosynthetic process] GO:0006707 [cholesterol catabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007399 [nervous system development] GO:0008206 [bile acid metabolic process] GO:0008395 [steroid hydroxylase activity] GO:0016021 [integral component of membrane] GO:0016125 [sterol metabolic process] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0033781 [cholesterol 24-hydroxylase activity] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	500 aa 56.8 kDa	Yes	0
CYP46A1-003 ENSP00000369577 ENST00000380228	Q9Y6A2 [Direct mapping] Cholesterol 24-hydroxylase Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005506 [iron ion binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006699 [bile acid biosynthetic process] GO:0006707 [cholesterol catabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007399 [nervous system development] GO:0008206 [bile acid metabolic process] GO:0008395 [steroid hydroxylase activity] GO:0016021 [integral component of membrane] GO:0016125 [sterol metabolic process] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0033781 [cholesterol 24-hydroxylase activity] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	403 aa 46 kDa	No	0
CYP46A1-006 ENSP00000451602 ENST00000556313	H0YJI0 [Direct mapping] Cholesterol 24-hydroxylase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	164 aa 18.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.