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CYP46A1

GENERAL INFORMATION

Gene name

 CYP46A1

Gene description

 Cytochrome P450, family 46, subfamily A, polypeptide 1

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Group enriched (AF22, U-937)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending retesting.

Reliability score

 Uncertain based on 1 antibody.
HPA040702
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040702

GENE INFORMATION

Gene name

 CYP46A1 (HGNC Symbol)

Synonyms

 CYP46

Description

 Cytochrome P450, family 46, subfamily A, polypeptide 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q32.2

Chromosome location (bp)

 99684304 - 99727301

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000036530 (version 83.38)

Entrez gene

 10858

UniProt

 Q9Y6A2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6A2

Antibodypedia

 CYP46A1 antibodies

PROTEIN BROWSER
CYP46A1-001
CYP46A1-003
CYP46A1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYP46A1-001
ENSP00000261835
ENST00000261835
Q9Y6A2 [Direct mapping]
Cholesterol 24-hydroxylase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Kim et al 2014)
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GO:0005506 [iron ion binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006699 [bile acid biosynthetic process]
GO:0006707 [cholesterol catabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007399 [nervous system development]
GO:0008206 [bile acid metabolic process]
GO:0008395 [steroid hydroxylase activity]
GO:0016021 [integral component of membrane]
GO:0016125 [sterol metabolic process]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0033781 [cholesterol 24-hydroxylase activity]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
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 500 aa
56.8 kDa 		Yes 0
CYP46A1-003
ENSP00000369577
ENST00000380228
Q9Y6A2 [Direct mapping]
Cholesterol 24-hydroxylase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005506 [iron ion binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006699 [bile acid biosynthetic process]
GO:0006707 [cholesterol catabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007399 [nervous system development]
GO:0008206 [bile acid metabolic process]
GO:0008395 [steroid hydroxylase activity]
GO:0016021 [integral component of membrane]
GO:0016125 [sterol metabolic process]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0033781 [cholesterol 24-hydroxylase activity]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
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 403 aa
46 kDa 		No 0
CYP46A1-006
ENSP00000451602
ENST00000556313
H0YJI0 [Direct mapping]
Cholesterol 24-hydroxylase
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005506 [iron ion binding]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
 164 aa
18.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.