Expression of SLC18A1 in cancer - Summary

GENERAL INFORMATION
Gene name	SLC18A1
Gene description	Solute carrier family 18 (vesicular monoamine transporter), member 1
Protein class	FDA approved drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (colorectal cancer)
HPA (cell line):	Cell line enriched (SH-SY5Y)
HPA (normal tissue):	Tissue enriched (adrenal gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in adrenal medulla and enteroendocrine cells in the gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA006877 , HPA063797
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA006877	HPA063797

GENE INFORMATION
Gene name	SLC18A1 (HGNC Symbol)
Synonyms	CGAT, VAT1, VMAT1
Description	Solute carrier family 18 (vesicular monoamine transporter), member 1 (HGNC Symbol)
Entrez gene summary	The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	20144855 - 20183206
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000036565 (version 83.38)
Entrez gene	6570
UniProt	P54219 (UniProt - Evidence at transcript level)
neXtProt	NX_P54219
Antibodypedia	SLC18A1 antibodies

PROTEIN BROWSER

SLC18A1-001	SLC18A1-002	SLC18A1-003	SLC18A1-005	SLC18A1-008	SLC18A1-201	SLC18A1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC18A1-001 ENSP00000276373 ENST00000276373	P54219 [Direct mapping] Chromaffin granule amine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006855 [drug transmembrane transport] GO:0008504 [monoamine transmembrane transporter activity] GO:0015238 [drug transmembrane transporter activity] GO:0015844 [monoamine transport] GO:0015893 [drug transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane] Show all	525 aa 56.3 kDa	No	>9
SLC18A1-002 ENSP00000265808 ENST00000265808	P54219 [Direct mapping] Chromaffin granule amine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006855 [drug transmembrane transport] GO:0008504 [monoamine transmembrane transporter activity] GO:0015238 [drug transmembrane transporter activity] GO:0015844 [monoamine transport] GO:0015893 [drug transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane] Show all	493 aa 52.7 kDa	No	>9
SLC18A1-003 ENSP00000429664 ENST00000519026	P54219 [Direct mapping] Chromaffin granule amine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006855 [drug transmembrane transport] GO:0008504 [monoamine transmembrane transporter activity] GO:0015238 [drug transmembrane transporter activity] GO:0015844 [monoamine transport] GO:0015893 [drug transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane] Show all	493 aa 52.7 kDa	No	>9
SLC18A1-005 ENSP00000428999 ENST00000522513	E5RK12 [Direct mapping] Chromaffin granule amine transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	258 aa 27.7 kDa	No	4
SLC18A1-008 ENSP00000371021 ENST00000381608	P54219 [Direct mapping] Chromaffin granule amine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006855 [drug transmembrane transport] GO:0008504 [monoamine transmembrane transporter activity] GO:0015238 [drug transmembrane transporter activity] GO:0015844 [monoamine transport] GO:0015893 [drug transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane] Show all	472 aa 50 kDa	No	>9
SLC18A1-201 ENSP00000413361 ENST00000437980	P54219 [Direct mapping] Chromaffin granule amine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006855 [drug transmembrane transport] GO:0008504 [monoamine transmembrane transporter activity] GO:0015238 [drug transmembrane transporter activity] GO:0015844 [monoamine transport] GO:0015893 [drug transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane] Show all	472 aa 50 kDa	No	>9
SLC18A1-202 ENSP00000387549 ENST00000440926	P54219 [Direct mapping] Chromaffin granule amine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006855 [drug transmembrane transport] GO:0008504 [monoamine transmembrane transporter activity] GO:0015222 [serotonin transmembrane transporter activity] GO:0015238 [drug transmembrane transporter activity] GO:0015844 [monoamine transport] GO:0015893 [drug transport] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0033603 [positive regulation of dopamine secretion] GO:0051610 [serotonin uptake] GO:0051612 [negative regulation of serotonin uptake] GO:0055085 [transmembrane transport] GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane] GO:0071285 [cellular response to lithium ion] Show all	525 aa 56.3 kDa	No	>9