Tissue expression of SLC18A1 - Summary - The Human Protein Atlas

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SLC18A1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SLC18A1
Gene description	Solute carrier family 18 (vesicular monoamine transporter), member 1
Protein class	FDA approved drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (adrenal gland)
GTEx:	Group enriched (adrenal gland, small intestine)
FANTOM5:	Group enriched (colon, seminal vesicle, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Distinct expression in adrenal medulla and enteroendocrine cells in the gastrointestinal tract.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA006877 , HPA063797
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (adrenal gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (adrenal gland, small intestine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (colon, seminal vesicle, small intestine)

GENE INFORMATION
Gene name	SLC18A1 (HGNC Symbol)
Synonyms	CGAT, VAT1, VMAT1
Description	Solute carrier family 18 (vesicular monoamine transporter), member 1 (HGNC Symbol)
Entrez gene summary	The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	20144855 - 20183206
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000036565 (version 83.38)
Entrez gene	6570
UniProt	P54219 (UniProt - Evidence at transcript level)
neXtProt	NX_P54219
Antibodypedia	SLC18A1 antibodies

PROTEIN BROWSER

SLC18A1-001	SLC18A1-002	SLC18A1-003	SLC18A1-005	SLC18A1-008	SLC18A1-201	SLC18A1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC18A1-001 ENSP00000276373 ENST00000276373	P54219 [Direct mapping] Chromaffin granule amine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006855 [drug transmembrane transport] GO:0008504 [monoamine transmembrane transporter activity] GO:0015238 [drug transmembrane transporter activity] GO:0015844 [monoamine transport] GO:0015893 [drug transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane] Show all	525 aa 56.3 kDa	No	>9
SLC18A1-002 ENSP00000265808 ENST00000265808	P54219 [Direct mapping] Chromaffin granule amine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006855 [drug transmembrane transport] GO:0008504 [monoamine transmembrane transporter activity] GO:0015238 [drug transmembrane transporter activity] GO:0015844 [monoamine transport] GO:0015893 [drug transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane] Show all	493 aa 52.7 kDa	No	>9
SLC18A1-003 ENSP00000429664 ENST00000519026	P54219 [Direct mapping] Chromaffin granule amine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006855 [drug transmembrane transport] GO:0008504 [monoamine transmembrane transporter activity] GO:0015238 [drug transmembrane transporter activity] GO:0015844 [monoamine transport] GO:0015893 [drug transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane] Show all	493 aa 52.7 kDa	No	>9
SLC18A1-005 ENSP00000428999 ENST00000522513	E5RK12 [Direct mapping] Chromaffin granule amine transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	258 aa 27.7 kDa	No	4
SLC18A1-008 ENSP00000371021 ENST00000381608	P54219 [Direct mapping] Chromaffin granule amine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006855 [drug transmembrane transport] GO:0008504 [monoamine transmembrane transporter activity] GO:0015238 [drug transmembrane transporter activity] GO:0015844 [monoamine transport] GO:0015893 [drug transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane] Show all	472 aa 50 kDa	No	>9
SLC18A1-201 ENSP00000413361 ENST00000437980	P54219 [Direct mapping] Chromaffin granule amine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006855 [drug transmembrane transport] GO:0008504 [monoamine transmembrane transporter activity] GO:0015238 [drug transmembrane transporter activity] GO:0015844 [monoamine transport] GO:0015893 [drug transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane] Show all	472 aa 50 kDa	No	>9
SLC18A1-202 ENSP00000387549 ENST00000440926	P54219 [Direct mapping] Chromaffin granule amine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006855 [drug transmembrane transport] GO:0008504 [monoamine transmembrane transporter activity] GO:0015222 [serotonin transmembrane transporter activity] GO:0015238 [drug transmembrane transporter activity] GO:0015844 [monoamine transport] GO:0015893 [drug transport] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0033603 [positive regulation of dopamine secretion] GO:0051610 [serotonin uptake] GO:0051612 [negative regulation of serotonin uptake] GO:0055085 [transmembrane transport] GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane] GO:0071285 [cellular response to lithium ion] Show all	525 aa 56.3 kDa	No	>9

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.