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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CDH1
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  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CDH1

Gene description

Cadherin 1, type 1

Protein class

Cancer-related genes
CD markers
Disease related genes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BEWO, CAPAN-2, HaCaT)
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in epithelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 6 antibodies.
HPA004812 , CAB000087 , CAB028364 , CAB072855 , CAB072856 , CAB072857
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA004812
CAB000087
CAB028364
CAB072855
CAB072856
CAB072857

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong membranous staining in most cancer tissues. Lymphomas and gliomas and most renal cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues showed moderate to strong membrane positivity, additional cytoplasmic positivity in several cancers. Gliomas and lymphomas were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells displayed moderate to strong membranous staining with the exception of gliomas, lymphomas and several renal cancers, which were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong membranous staining in most cancer tissues. Tumor stroma, gliomas, lymphomas, renal cancers and most melanomas were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong membranous staining in all cancer tissues except gliomas, lymphomas and most renal carcinomas.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong membranous staining of most cancer tissues. Gliomas, lymphomas, renal cancers and most melanomas were negative.

GENE INFORMATION

Gene name

CDH1 (HGNC Symbol)

Synonyms

CD324, UVO, uvomorulin

Description

Cadherin 1, type 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]

Chromosome

16

Cytoband

q22.1

Chromosome location (bp)

68737225 - 68835548

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000039068 (version 83.38)

Entrez gene

999

UniProt

P12830 (UniProt - Evidence at protein level)

neXtProt

NX_P12830

Antibodypedia

CDH1 antibodies

PROTEIN BROWSER

CDH1-001
CDH1-004
CDH1-201
CDH1-202
CDH1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDH1-001
ENSP00000261769
ENST00000261769
P12830 [Direct mapping]
Cadherin-1 E-Cad/CTF1 E-Cad/CTF2 E-Cad/CTF3
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001948 [glycoprotein binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007416 [synapse assembly]
GO:0008013 [beta-catenin binding]
GO:0009636 [response to toxic substance]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0012501 [programmed cell death]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016235 [aggresome]
GO:0016328 [lateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016342 [catenin complex]
GO:0016600 [flotillin complex]
GO:0021983 [pituitary gland development]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0022617 [extracellular matrix disassembly]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030198 [extracellular matrix organization]
GO:0030506 [ankyrin binding]
GO:0030864 [cortical actin cytoskeleton]
GO:0031175 [neuron projection development]
GO:0032794 [GTPase activating protein binding]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042493 [response to drug]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043296 [apical junction complex]
GO:0045216 [cell-cell junction organization]
GO:0045295 [gamma-catenin binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050776 [regulation of immune response]
GO:0050839 [cell adhesion molecule binding]
GO:0070062 [extracellular exosome]
GO:0071285 [cellular response to lithium ion]
GO:0071681 [cellular response to indole-3-methanol]
GO:0072659 [protein localization to plasma membrane]
GO:0090002 [establishment of protein localization to plasma membrane]
Show all
882 aa
97.5 kDa
Yes 1
CDH1-004
ENSP00000414946
ENST00000422392
P12830 [Direct mapping]
Cadherin-1 E-Cad/CTF1 E-Cad/CTF2 E-Cad/CTF3
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001948 [glycoprotein binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008013 [beta-catenin binding]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0012501 [programmed cell death]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016235 [aggresome]
GO:0016328 [lateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016342 [catenin complex]
GO:0016600 [flotillin complex]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0022617 [extracellular matrix disassembly]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030198 [extracellular matrix organization]
GO:0030506 [ankyrin binding]
GO:0030864 [cortical actin cytoskeleton]
GO:0032794 [GTPase activating protein binding]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043296 [apical junction complex]
GO:0045216 [cell-cell junction organization]
GO:0045295 [gamma-catenin binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050776 [regulation of immune response]
GO:0050839 [cell adhesion molecule binding]
GO:0070062 [extracellular exosome]
GO:0071285 [cellular response to lithium ion]
GO:0071681 [cellular response to indole-3-methanol]
GO:0072659 [protein localization to plasma membrane]
GO:0090002 [establishment of protein localization to plasma membrane]
Show all
821 aa
90.9 kDa
Yes 1
CDH1-201
ENSP00000481063
ENST00000611625
A0A087WXI5 [Direct mapping]
Cadherin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
903 aa
100 kDa
Yes 1
CDH1-202
ENSP00000478360
ENST00000612417
A0A087WU43 [Direct mapping]
Cadherin-1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
Show all
647 aa
71.3 kDa
Yes 0
CDH1-203
ENSP00000480664
ENST00000621016
A0A087WX17 [Direct mapping]
Cadherin-1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
Show all
647 aa
71.4 kDa
Yes 0

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