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DNAH5

GENERAL INFORMATION

Gene name

 DNAH5

Gene description

 Dynein, axonemal, heavy chain 5

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (prostate cancer)
HPA (cell line):Cell line enhanced (BJ hTERT+, PC-3, RPTEC TERT1)
HPA (normal tissue):Tissue enhanced (fallopian tube, lung)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression in cilia in fallopian tube and respiratory epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Protein expression in respiratory epithelia can be correlated with lung RNA-seq data.

Reliability score

 Supported based on 2 antibodies.
HPA037469 , HPA037470
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037469
HPA037470

GENE INFORMATION

Gene name

 DNAH5 (HGNC Symbol)

Synonyms

 CILD3, Dnahc5, HL1, KTGNR, PCD

Description

 Dynein, axonemal, heavy chain 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009]

Chromosome

 5

Cytoband

 p15.2

Chromosome location (bp)

 13690331 - 13944543

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000039139 (version 83.38)

Entrez gene

 1767

UniProt

 Q8TE73 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TE73

Antibodypedia

 DNAH5 antibodies

PROTEIN BROWSER
DNAH5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNAH5-001
ENSP00000265104
ENST00000265104
Q8TE73 [Direct mapping]
Dynein heavy chain 5, axonemal
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   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
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GO:0003341 [cilium movement]
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005858 [axonemal dynein complex]
GO:0005874 [microtubule]
GO:0005930 [axoneme]
GO:0007018 [microtubule-based movement]
GO:0007368 [determination of left/right symmetry]
GO:0007507 [heart development]
GO:0008150 [biological_process]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
GO:0021670 [lateral ventricle development]
GO:0030286 [dynein complex]
GO:0030317 [sperm motility]
GO:0036157 [outer dynein arm]
GO:0036158 [outer dynein arm assembly]
GO:0042384 [cilium assembly]
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 4624 aa
529 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.