Cell atlas - LSG1 - The Human Protein Atlas

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LSG1

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	LSG1
Gene description	Large 60S subunit nuclear export GTPase 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & nuclear bodies. In addition localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (supported), Cytosol (supported)
Additional location	In addition localized to the Nucleus (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA037704
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & nuclear bodies. In addition localized to the nucleus.

Main location

Nuclear bodies (supported), Cytosol (supported)

Additional location

Nucleus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA037704	A-431	Nucleus
	HPA037704	A-431	Cytosol
	HPA037704	U-2 OS	Nucleus
			Nuclear bodies	Intensity
			Cytosol
	HPA037704	U-251 MG	Nucleus
			Nuclear bodies	Intensity
			Cytosol

GENE INFORMATION
Gene name	LSG1 (HGNC Symbol)
Synonyms	FLJ11301
Description	Large 60S subunit nuclear export GTPase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein related to the yeast large subunit GTPase 1. The encoded protein is necessary for cell viability and may localize in the endoplasmic reticulum, nucleus and cytoplasm.[provided by RefSeq, Feb 2009]
Chromosome	3
Cytoband	q29
Chromosome location (bp)	194640788 - 194672477
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000041802 (version 83.38)
Entrez gene	55341
UniProt	Q9H089 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H089
Antibodypedia	LSG1 antibodies

PROTEIN BROWSER

LSG1-001	LSG1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LSG1-001 ENSP00000265245 ENST00000265245	Q9H089 [Direct mapping] Large subunit GTPase 1 homolog Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0008152 [metabolic process] GO:0015030 [Cajal body] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0042254 [ribosome biogenesis] GO:0051168 [nuclear export] Show all	658 aa 75.2 kDa	No	0
LSG1-004 ENSP00000408264 ENST00000437613	H7C2X7 [Direct mapping] Large subunit GTPase 1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005829 [cytosol] GO:0042254 [ribosome biogenesis] Show all	285 aa 31.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.