Expression of LSG1 in cancer - Summary - The Human Protein Atlas

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LSG1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LSG1
Gene description	Large 60S subunit nuclear export GTPase 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA037704 , HPA037705
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037704	HPA037705

GENE INFORMATION
Gene name	LSG1 (HGNC Symbol)
Synonyms	FLJ11301
Description	Large 60S subunit nuclear export GTPase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein related to the yeast large subunit GTPase 1. The encoded protein is necessary for cell viability and may localize in the endoplasmic reticulum, nucleus and cytoplasm.[provided by RefSeq, Feb 2009]
Chromosome	3
Cytoband	q29
Chromosome location (bp)	194640788 - 194672477
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000041802 (version 83.38)
Entrez gene	55341
UniProt	Q9H089 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H089
Antibodypedia	LSG1 antibodies

PROTEIN BROWSER

LSG1-001	LSG1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LSG1-001 ENSP00000265245 ENST00000265245	Q9H089 [Direct mapping] Large subunit GTPase 1 homolog Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0008152 [metabolic process] GO:0015030 [Cajal body] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0042254 [ribosome biogenesis] GO:0051168 [nuclear export] Show all	658 aa 75.2 kDa	No	0
LSG1-004 ENSP00000408264 ENST00000437613	H7C2X7 [Direct mapping] Large subunit GTPase 1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005829 [cytosol] GO:0042254 [ribosome biogenesis] Show all	285 aa 31.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.