Cell atlas - MAGEC2 - The Human Protein Atlas

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MAGEC2

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli
	Nucleus

Human cell
	Cytosol
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MAGEC2
Gene description	Melanoma antigen family C2
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & cytosol. In addition localized to the nucleoli.
RNA cell category	Group enriched (K-562, U-266/84)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported), Cytosol (supported)
Additional location	In addition localized to the Nucleoli (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA062230
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (K-562, U-266/84) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & cytosol. In addition localized to the nucleoli.

Main location

Nucleus (supported), Cytosol (supported)

Additional location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA062230	A-431	Nucleoplasm
	HPA062230	A-431	Cytosol
	HPA062230	SK-MEL-30	Nucleus	Intensity
	HPA062230	SK-MEL-30	Nucleoli	Intensity
	HPA062230	U-2 OS	Nucleus	Intensity
	HPA062230	U-2 OS	Cytosol

GENE INFORMATION
Gene name	MAGEC2 (HGNC Symbol)
Synonyms	CT10, MAGE-C2, MAGEE1
Description	Melanoma antigen family C2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009]
Chromosome	X
Cytoband	q27.2
Chromosome location (bp)	142202345 - 142205290
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000046774 (version 83.38)
Entrez gene	51438
UniProt	Q9UBF1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBF1
Antibodypedia	MAGEC2 antibodies

PROTEIN BROWSER

MAGEC2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAGEC2-001 ENSP00000354660 ENST00000247452	Q9UBF1 [Direct mapping] Melanoma-associated antigen C2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0031625 [ubiquitin protein ligase binding] GO:0044257 [cellular protein catabolic process] GO:0051443 [positive regulation of ubiquitin-protein transferase activity] Show all	373 aa 41.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.