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MAGEC2

GENERAL INFORMATION

Gene name

 MAGEC2

Gene description

 Melanoma antigen family C2

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (melanoma)
HPA (cell line):Group enriched (K-562, U-266/84)
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective nuclear expression in testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA062230
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (melanoma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA062230

GENE INFORMATION

Gene name

 MAGEC2 (HGNC Symbol)

Synonyms

 CT10, MAGE-C2, MAGEE1

Description

 Melanoma antigen family C2 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009]

Chromosome

 X

Cytoband

 q27.2

Chromosome location (bp)

 142202345 - 142205290

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000046774 (version 83.38)

Entrez gene

 51438

UniProt

 Q9UBF1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBF1

Antibodypedia

 MAGEC2 antibodies

PROTEIN BROWSER
MAGEC2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAGEC2-001
ENSP00000354660
ENST00000247452
Q9UBF1 [Direct mapping]
Melanoma-associated antigen C2
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044257 [cellular protein catabolic process]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
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 373 aa
41.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.