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TPR

GENERAL INFORMATION

Gene name

 TPR

Gene description

 Translocated promoter region, nuclear basket protein

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear and nuclear membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA019661 , HPA019663 , HPA024336
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and head and neck cancer (favourable).
Liver cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA019661
HPA019663
HPA024336

GENE INFORMATION

Gene name

 TPR

Synonyms

Description

 Translocated promoter region, nuclear basket protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q31.1

Chromosome location (bp)

 186311652 - 186375693

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000047410 (version 83.38)

Entrez gene

 7175

UniProt

 P12270 (UniProt - Evidence at protein level)

neXtProt

 NX_P12270

Antibodypedia

 TPR antibodies

PROTEIN BROWSER
TPR-001
TPR-003
TPR-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TPR-001
ENSP00000356448
ENST00000367478
P12270 [Direct mapping]
Nucleoprotein TPR
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000189 [MAPK import into nucleus]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0003674 [molecular_function]
GO:0003682 [chromatin binding]
GO:0003729 [mRNA binding]
GO:0005487 [nucleocytoplasmic transporter activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005868 [cytoplasmic dynein complex]
GO:0005975 [carbohydrate metabolic process]
GO:0006404 [RNA import into nucleus]
GO:0006405 [RNA export from nucleus]
GO:0006606 [protein import into nucleus]
GO:0006611 [protein export from nucleus]
GO:0006999 [nuclear pore organization]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008033 [tRNA processing]
GO:0008150 [biological_process]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0010965 [regulation of mitotic sister chromatid separation]
GO:0015631 [tubulin binding]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019898 [extrinsic component of membrane]
GO:0031047 [gene silencing by RNA]
GO:0031072 [heat shock protein binding]
GO:0031453 [positive regulation of heterochromatin assembly]
GO:0031965 [nuclear membrane]
GO:0031990 [mRNA export from nucleus in response to heat stress]
GO:0034399 [nuclear periphery]
GO:0034605 [cellular response to heat]
GO:0035457 [cellular response to interferon-alpha]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042405 [nuclear inclusion body]
GO:0042803 [protein homodimerization activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044615 [nuclear pore nuclear basket]
GO:0044822 [poly(A) RNA binding]
GO:0045947 [negative regulation of translational initiation]
GO:0046827 [positive regulation of protein export from nucleus]
GO:0046832 [negative regulation of RNA export from nucleus]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051301 [cell division]
GO:0055085 [transmembrane transport]
GO:0070840 [dynein complex binding]
GO:0070849 [response to epidermal growth factor]
GO:0072686 [mitotic spindle]
GO:0090267 [positive regulation of mitotic cell cycle spindle assembly checkpoint]
GO:0090316 [positive regulation of intracellular protein transport]
GO:1900034 [regulation of cellular response to heat]
GO:1901673 [regulation of mitotic spindle assembly]
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 2363 aa
267.3 kDa 		No 0
TPR-003
ENSP00000408103
ENST00000451586
Q5SWX9 [Direct mapping]
Nucleoprotein TPR
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 150 aa
16.5 kDa 		No 0
TPR-201
ENSP00000483425
ENST00000613151
P12270 [Direct mapping]
Nucleoprotein TPR
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000189 [MAPK import into nucleus]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0003674 [molecular_function]
GO:0003682 [chromatin binding]
GO:0003729 [mRNA binding]
GO:0005487 [nucleocytoplasmic transporter activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005868 [cytoplasmic dynein complex]
GO:0005975 [carbohydrate metabolic process]
GO:0006404 [RNA import into nucleus]
GO:0006405 [RNA export from nucleus]
GO:0006999 [nuclear pore organization]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008033 [tRNA processing]
GO:0008150 [biological_process]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0010965 [regulation of mitotic sister chromatid separation]
GO:0015631 [tubulin binding]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019898 [extrinsic component of membrane]
GO:0031047 [gene silencing by RNA]
GO:0031072 [heat shock protein binding]
GO:0031453 [positive regulation of heterochromatin assembly]
GO:0031965 [nuclear membrane]
GO:0031990 [mRNA export from nucleus in response to heat stress]
GO:0034399 [nuclear periphery]
GO:0034605 [cellular response to heat]
GO:0035457 [cellular response to interferon-alpha]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042405 [nuclear inclusion body]
GO:0042803 [protein homodimerization activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044615 [nuclear pore nuclear basket]
GO:0044822 [poly(A) RNA binding]
GO:0045947 [negative regulation of translational initiation]
GO:0046827 [positive regulation of protein export from nucleus]
GO:0046832 [negative regulation of RNA export from nucleus]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051301 [cell division]
GO:0055085 [transmembrane transport]
GO:0070840 [dynein complex binding]
GO:0070849 [response to epidermal growth factor]
GO:0072686 [mitotic spindle]
GO:0090267 [positive regulation of mitotic cell cycle spindle assembly checkpoint]
GO:0090316 [positive regulation of intracellular protein transport]
GO:1900034 [regulation of cellular response to heat]
GO:1901673 [regulation of mitotic spindle assembly]
Show all
 726 aa
84 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.