Cell atlas - ANO2 - The Human Protein Atlas

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ANO2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Plasma membrane

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	ANO2
Gene description	Anoctamin 2, calcium activated chloride channel
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the nucleoplasm.
RNA cell category	Cell line enhanced (U-2 OS, HUVEC TERT2, BJ hTERT+)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA036276
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2 OS, HUVEC TERT2, BJ hTERT+) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the nucleoplasm.

Main location

Plasma membrane (supported)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036276	A-431	Nucleoplasm
	HPA036276	A-431	Plasma membrane
	HPA036276	U-2 OS	Nucleoplasm
	HPA036276	U-2 OS	Plasma membrane
	HPA036276	U-251 MG	Nucleoplasm
	HPA036276	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	ANO2 (HGNC Symbol)
Synonyms	C12orf3, TMEM16B
Description	Anoctamin 2, calcium activated chloride channel (HGNC Symbol)
Entrez gene summary	ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 [PubMed 19015192]).[supplied by OMIM, Jan 2011]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	5531869 - 5946232
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000047617 (version 83.38)
Entrez gene	57101
UniProt	Q9NQ90 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQ90
Antibodypedia	ANO2 antibodies

PROTEIN BROWSER

ANO2-001	ANO2-005	ANO2-201	ANO2-202	ANO2-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANO2-001 ENSP00000348453 ENST00000356134	Q9NQ90 [Direct mapping] Anoctamin-2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005229 [intracellular calcium activated chloride channel activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] GO:0006821 [chloride transport] GO:0031513 [nonmotile primary cilium] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0042803 [protein homodimerization activity] GO:0046982 [protein heterodimerization activity] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	999 aa 113.6 kDa	No	8
ANO2-005 ENSP00000443813 ENST00000545860	F5H806 [Direct mapping] Anoctamin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005229 [intracellular calcium activated chloride channel activity] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:1902476 [chloride transmembrane transport] Show all	203 aa 23.5 kDa	No	3
ANO2-201 ENSP00000314048 ENST00000327087	Q9NQ90 [Direct mapping] Anoctamin-2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005229 [intracellular calcium activated chloride channel activity] GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	999 aa 113.6 kDa	No	8
ANO2-202 ENSP00000440981 ENST00000546188	F5GXT3 [Direct mapping] Anoctamin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005229 [intracellular calcium activated chloride channel activity] GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:1902476 [chloride transmembrane transport] Show all	1003 aa 113.9 kDa	No	8
ANO2-203 ENSP00000481449 ENST00000612575	Q69YW4 [Direct mapping] Anoctamin-2; Putative uncharacterized protein DKFZp434P102 Show all	Predicted intracellular proteins Show all	GO:0005229 [intracellular calcium activated chloride channel activity] GO:0005886 [plasma membrane] GO:1902476 [chloride transmembrane transport] Show all	86 aa 9.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.