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A few cases of squamous cell carcinomas, malignant melanomas, colorectal and pancreatic cancers showed moderate nucleolar immunoreactivity. A single case of hepatocellular carcinoma was strongly stained. Remaining cancer tissues were negative.
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]